Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477834734> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2477834734 endingPage "704" @default.
- W2477834734 startingPage "698" @default.
- W2477834734 abstract "The intracellular transport of organelles and protein complexes is mediated by kinesin superfamily proteins (KIFs). The first kinesin, kinesin 1, was identified as a molecular motor protein that moves various organelles and protein complexes along the microtubule rails in cells. Kinesin 1 is a tetramer of two heavy chains (KHCs, also called KIF5s) and two kinesin light chains (KLCs). KIF5s interact with many different proteins through their tail region, but their binding proteins have not yet been fully identified. To identify the interaction proteins for KIF5A, we performed yeast two-hybrid screening and found a specific interaction with ferritin heavy chain (Frt-h), which has a role in iron storage and detoxification. Frt-h bound to the amino acid residues between 800 and 940 of KIF5A and to other KIF5s in the yeast two-hybrid assay. The coiled-coil domain of Frt-h is essential for interaction with KIF5A. In addition, ferritin light chain (Frt-l) interacted with KIF5s in the yeast two-hybrid assay. In addition, these proteins showed specific interactions in the glutathione S-transferase (GST) pull-down assay. An antibody to KHC specifically co-immunoprecipitated Frt-h and Frt-l from mouse brain extracts. These results suggest the kinesin 1 motor protein may transport the ferritin complex in cells." @default.
- W2477834734 created "2016-08-23" @default.
- W2477834734 creator A5004319038 @default.
- W2477834734 creator A5010530412 @default.
- W2477834734 creator A5014165567 @default.
- W2477834734 creator A5021270019 @default.
- W2477834734 creator A5022290263 @default.
- W2477834734 creator A5067406841 @default.
- W2477834734 creator A5083682647 @default.
- W2477834734 creator A5087300857 @default.
- W2477834734 date "2016-06-30" @default.
- W2477834734 modified "2023-10-15" @default.
- W2477834734 title "Ferritin, an Iron Storage Protein, Associates with Kinesin 1 through the Cargo-binding Region of Kinesin Heavy Chains (KHCs)" @default.
- W2477834734 cites W1515013277 @default.
- W2477834734 cites W1554281767 @default.
- W2477834734 cites W1597336164 @default.
- W2477834734 cites W1970356391 @default.
- W2477834734 cites W1978104052 @default.
- W2477834734 cites W1978547782 @default.
- W2477834734 cites W1979026517 @default.
- W2477834734 cites W1983043263 @default.
- W2477834734 cites W1985812526 @default.
- W2477834734 cites W1987119816 @default.
- W2477834734 cites W1997216533 @default.
- W2477834734 cites W2003046281 @default.
- W2477834734 cites W2015890343 @default.
- W2477834734 cites W2023677478 @default.
- W2477834734 cites W2037091801 @default.
- W2477834734 cites W2053626372 @default.
- W2477834734 cites W2061272721 @default.
- W2477834734 cites W2070144984 @default.
- W2477834734 cites W2077740413 @default.
- W2477834734 cites W2087670043 @default.
- W2477834734 cites W2092729353 @default.
- W2477834734 cites W2095749546 @default.
- W2477834734 cites W2119605126 @default.
- W2477834734 cites W2125744986 @default.
- W2477834734 cites W2132583909 @default.
- W2477834734 cites W2136272161 @default.
- W2477834734 cites W2147353977 @default.
- W2477834734 cites W2407918861 @default.
- W2477834734 doi "https://doi.org/10.5352/jls.2016.26.6.698" @default.
- W2477834734 hasPublicationYear "2016" @default.
- W2477834734 type Work @default.
- W2477834734 sameAs 2477834734 @default.
- W2477834734 citedByCount "1" @default.
- W2477834734 countsByYear W24778347342019 @default.
- W2477834734 crossrefType "journal-article" @default.
- W2477834734 hasAuthorship W2477834734A5004319038 @default.
- W2477834734 hasAuthorship W2477834734A5010530412 @default.
- W2477834734 hasAuthorship W2477834734A5014165567 @default.
- W2477834734 hasAuthorship W2477834734A5021270019 @default.
- W2477834734 hasAuthorship W2477834734A5022290263 @default.
- W2477834734 hasAuthorship W2477834734A5067406841 @default.
- W2477834734 hasAuthorship W2477834734A5083682647 @default.
- W2477834734 hasAuthorship W2477834734A5087300857 @default.
- W2477834734 hasBestOaLocation W24778347341 @default.
- W2477834734 hasConcept C12554922 @default.
- W2477834734 hasConcept C185592680 @default.
- W2477834734 hasConcept C20418707 @default.
- W2477834734 hasConcept C2778319317 @default.
- W2477834734 hasConcept C55493867 @default.
- W2477834734 hasConcept C59006786 @default.
- W2477834734 hasConcept C86803240 @default.
- W2477834734 hasConcept C95444343 @default.
- W2477834734 hasConceptScore W2477834734C12554922 @default.
- W2477834734 hasConceptScore W2477834734C185592680 @default.
- W2477834734 hasConceptScore W2477834734C20418707 @default.
- W2477834734 hasConceptScore W2477834734C2778319317 @default.
- W2477834734 hasConceptScore W2477834734C55493867 @default.
- W2477834734 hasConceptScore W2477834734C59006786 @default.
- W2477834734 hasConceptScore W2477834734C86803240 @default.
- W2477834734 hasConceptScore W2477834734C95444343 @default.
- W2477834734 hasIssue "6" @default.
- W2477834734 hasLocation W24778347341 @default.
- W2477834734 hasOpenAccess W2477834734 @default.
- W2477834734 hasPrimaryLocation W24778347341 @default.
- W2477834734 hasRelatedWork W1974528900 @default.
- W2477834734 hasRelatedWork W2025337933 @default.
- W2477834734 hasRelatedWork W2036767683 @default.
- W2477834734 hasRelatedWork W2091703464 @default.
- W2477834734 hasRelatedWork W2126904219 @default.
- W2477834734 hasRelatedWork W2146861670 @default.
- W2477834734 hasRelatedWork W2762659278 @default.
- W2477834734 hasRelatedWork W3130155154 @default.
- W2477834734 hasRelatedWork W4298088849 @default.
- W2477834734 hasRelatedWork W856257648 @default.
- W2477834734 hasVolume "26" @default.
- W2477834734 isParatext "false" @default.
- W2477834734 isRetracted "false" @default.
- W2477834734 magId "2477834734" @default.
- W2477834734 workType "article" @default.