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- W2477963580 abstract "Abstract Neuroactive steroids (NASs) are a family of steroid-based compounds of both natural and synthetic origin, which have been shown to impact central nervous system function through allosteric modulation of the GABA(γ-aminobutyric acid)A receptor and the NMDA ( N -methyl- d -aspartic acid) class of glutamate receptors. Respectively, these are two of the major inhibitory and excitatory neurotransmitter receptor families involved in synaptic transmission in the brain. Research over recent years has demonstrated that these receptors can be either positively (PAM) or negatively (NAM) allosterically modulated by NAS compounds, an action mediated through binding to allosteric sites. The focus of this report is to briefly review endogenous and synthetic NASs that target GABA A and NMDA receptors." @default.
- W2477963580 created "2016-08-23" @default.
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- W2477963580 date "2014-01-01" @default.
- W2477963580 modified "2023-09-27" @default.
- W2477963580 title "Natural and Synthetic Neuroactive Steroid Modulators of GABAA and NMDA Receptors" @default.
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- W2477963580 doi "https://doi.org/10.1016/b978-0-12-800167-7.00003-1" @default.
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