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• W2477992269 abstract "The anterior pituitary is an endocrine gland responsible for secreting hormones that regulate a wide range of functions. The traditional view of the anterior pituitary holds that there are five endocrine cell types, which are classified on the basis of the expression of a specific hormone and response to specific hypothalamic-releasing hormones. However, the recent finding of polyhormonal cells and multi-responsive cells may blur this division. In addition, remarkable heterogeneity is observed within each of these cell types. An impressive signaling toolkit represented by a broad variety of receptors and ion channels, gives rise to distinctive patterns of electrical activity and Ca2+ signaling which in turn underlie cell type-specific secretion profiles. Intricate autocrine and paracrine interactions add another layer of complexity to their repertoire. These cells are not homogeneously distributed in the gland but form numerous intercrossing strands of single cells whose connectivity and location is remarkably dynamic. Experience-dependent plasticity has been recently shown for the lactotroph cell network, allowing adaptation to meet changing physiological demands, a feature that is likely shared by other endocrine cells to meet their vital role in homeostatic control." @default.
• W2477992269 created "2016-08-23" @default.
• W2477992269 creator A5035615115 @default.
• W2477992269 creator A5073723016 @default.
• W2477992269 date "2014-01-01" @default.
• W2477992269 modified "2023-09-25" @default.
• W2477992269 title "The Molecular Cell Biology of Anterior Pituitary Cells" @default.
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• W2477992269 doi "https://doi.org/10.1016/b978-0-12-408134-5.00002-0" @default.
• W2477992269 hasPublicationYear "2014" @default.
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