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- W2478137479 abstract "Background and Goal of study: Inappropriate titration of the anesthetic agents can lead to an under or excessive depth of anesthesia. Aim is to study effect of introducing Entropy monitoring during major liver resection among cirrhotic patients with chronic hepatitis C (Child A) undergoing major liver resection on general anesthetic requirements and hemodynamics.Methods: 60 consecutive patients were randomly divided into two groups in a prospective hospital based comparative study registered in Menoufiya University, Egypt. Group I guided with Entropy, Group II also guided with standard practice but obscured from Anaethesist. Sevoflurane with O2 /Air 50% at 2 l/min adjusted to achieve a State (SE) and Response (RE) Entropy (40-60 with a gradient of 5-10. Boluses of Fentanyl (1 - 2 μg/kg) were given if the difference between SE and RE was more than 10 for more than two minutes. Sevoflurane (ml) consumed were monitored by GE Datex-Ohemda S/5 Anesthetic Delivery Unit System.Results: Age, weight and fentanyl consumption were comparable between both groups (P >0.05). Mean (SD) Sevoflourane consumption (ml) after 2hr, 4hr, and 6hr in GI (Entropy) versus II (Standard) were 16(2.19) vs 20.8(1.88), 10.7(1.94) vs 17.4(1.92), and 9(1.22) vs 14.1(2.19), P 0.05. Anaesthesia time was comparable between both groups with the same surgical and an aesthetic team.Conclusion: Entropy monitoring for hepatic patients reduced general anaesthetic agent consumption during induction and surgery and enhanced recovery with favourable haemodynamic consequences. Encouraging the use of Anaesthesia depth monitors can have an important economic impact when applied on a larger scale." @default.
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- W2478137479 date "2016-07-28" @default.
- W2478137479 modified "2023-09-27" @default.
- W2478137479 title "Entropy Monitoring Effect in Hepatic Cirrhotic Patients Undergoing Major Liver Resection on Sevoflurane Consumption and Hemodynamics. A Randomized Controlled Study" @default.
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- W2478137479 doi "https://doi.org/10.15406/jaccoa.2016.05.00185" @default.
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