Matches in SemOpenAlex for { <https://semopenalex.org/work/W2478329635> ?p ?o ?g. }
- W2478329635 endingPage "378" @default.
- W2478329635 startingPage "365" @default.
- W2478329635 abstract "α-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose. Three series of tetracyclic oxindole derivatives were designed, synthesized and evaluated for α-glucosidase inhibitory activity in vitro. Compound 6t exhibited the most potent inhibitory activity with IC50 0.7 μM and was about 170 times as active as acarbose (IC50 = 115.8 μM). The kinetic analysis of compound 6t revealed it inhibited α-glucosidase in an irreversible and mixed manner. Fluorescence spectra indicated that 6t directly bound to α-glucosidase. Docking simulation showed the existence of potential H-bonding, van der Waals, Pi and Sigma-Pi interactions between 6t and α-glucosidase." @default.
- W2478329635 created "2016-08-23" @default.
- W2478329635 creator A5001971810 @default.
- W2478329635 creator A5015666622 @default.
- W2478329635 creator A5033077746 @default.
- W2478329635 creator A5034834769 @default.
- W2478329635 creator A5040731942 @default.
- W2478329635 creator A5046454314 @default.
- W2478329635 creator A5049692788 @default.
- W2478329635 creator A5052327884 @default.
- W2478329635 creator A5052873500 @default.
- W2478329635 creator A5054835425 @default.
- W2478329635 creator A5075524395 @default.
- W2478329635 creator A5079452042 @default.
- W2478329635 date "2016-11-01" @default.
- W2478329635 modified "2023-10-16" @default.
- W2478329635 title "Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors" @default.
- W2478329635 cites W1138321198 @default.
- W2478329635 cites W11891467 @default.
- W2478329635 cites W1612982626 @default.
- W2478329635 cites W1977862572 @default.
- W2478329635 cites W1987287280 @default.
- W2478329635 cites W1997644334 @default.
- W2478329635 cites W2016403352 @default.
- W2478329635 cites W2031860793 @default.
- W2478329635 cites W2032608371 @default.
- W2478329635 cites W2034313885 @default.
- W2478329635 cites W2035347883 @default.
- W2478329635 cites W2039154002 @default.
- W2478329635 cites W2051507935 @default.
- W2478329635 cites W2052320152 @default.
- W2478329635 cites W2059067578 @default.
- W2478329635 cites W2084150957 @default.
- W2478329635 cites W2108305553 @default.
- W2478329635 cites W2132013574 @default.
- W2478329635 cites W2153312739 @default.
- W2478329635 cites W2210616237 @default.
- W2478329635 cites W2300111395 @default.
- W2478329635 cites W2332101076 @default.
- W2478329635 cites W2952603356 @default.
- W2478329635 doi "https://doi.org/10.1016/j.ejmech.2016.07.044" @default.
- W2478329635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27487567" @default.
- W2478329635 hasPublicationYear "2016" @default.
- W2478329635 type Work @default.
- W2478329635 sameAs 2478329635 @default.
- W2478329635 citedByCount "34" @default.
- W2478329635 countsByYear W24783296352017 @default.
- W2478329635 countsByYear W24783296352018 @default.
- W2478329635 countsByYear W24783296352019 @default.
- W2478329635 countsByYear W24783296352020 @default.
- W2478329635 countsByYear W24783296352021 @default.
- W2478329635 countsByYear W24783296352022 @default.
- W2478329635 countsByYear W24783296352023 @default.
- W2478329635 crossrefType "journal-article" @default.
- W2478329635 hasAuthorship W2478329635A5001971810 @default.
- W2478329635 hasAuthorship W2478329635A5015666622 @default.
- W2478329635 hasAuthorship W2478329635A5033077746 @default.
- W2478329635 hasAuthorship W2478329635A5034834769 @default.
- W2478329635 hasAuthorship W2478329635A5040731942 @default.
- W2478329635 hasAuthorship W2478329635A5046454314 @default.
- W2478329635 hasAuthorship W2478329635A5049692788 @default.
- W2478329635 hasAuthorship W2478329635A5052327884 @default.
- W2478329635 hasAuthorship W2478329635A5052873500 @default.
- W2478329635 hasAuthorship W2478329635A5054835425 @default.
- W2478329635 hasAuthorship W2478329635A5075524395 @default.
- W2478329635 hasAuthorship W2478329635A5079452042 @default.
- W2478329635 hasConcept C159110408 @default.
- W2478329635 hasConcept C161790260 @default.
- W2478329635 hasConcept C181199279 @default.
- W2478329635 hasConcept C185592680 @default.
- W2478329635 hasConcept C202751555 @default.
- W2478329635 hasConcept C2776617576 @default.
- W2478329635 hasConcept C2777752497 @default.
- W2478329635 hasConcept C2780083155 @default.
- W2478329635 hasConcept C41685203 @default.
- W2478329635 hasConcept C55493867 @default.
- W2478329635 hasConcept C71240020 @default.
- W2478329635 hasConcept C71924100 @default.
- W2478329635 hasConceptScore W2478329635C159110408 @default.
- W2478329635 hasConceptScore W2478329635C161790260 @default.
- W2478329635 hasConceptScore W2478329635C181199279 @default.
- W2478329635 hasConceptScore W2478329635C185592680 @default.
- W2478329635 hasConceptScore W2478329635C202751555 @default.
- W2478329635 hasConceptScore W2478329635C2776617576 @default.
- W2478329635 hasConceptScore W2478329635C2777752497 @default.
- W2478329635 hasConceptScore W2478329635C2780083155 @default.
- W2478329635 hasConceptScore W2478329635C41685203 @default.
- W2478329635 hasConceptScore W2478329635C55493867 @default.
- W2478329635 hasConceptScore W2478329635C71240020 @default.
- W2478329635 hasConceptScore W2478329635C71924100 @default.
- W2478329635 hasFunder F4320321001 @default.
- W2478329635 hasLocation W24783296351 @default.
- W2478329635 hasLocation W24783296352 @default.
- W2478329635 hasOpenAccess W2478329635 @default.
- W2478329635 hasPrimaryLocation W24783296351 @default.
- W2478329635 hasRelatedWork W2803196848 @default.
- W2478329635 hasRelatedWork W2805853181 @default.
- W2478329635 hasRelatedWork W2963355712 @default.