FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2478374019> ?p ?o ?g. }

• W2478374019 endingPage "1169" @default.
• W2478374019 startingPage "1158" @default.
• W2478374019 abstract "ABSTRACT Natural products isolated from marine environment are well known for their pharmacodynamic potential in diversity of disease treatments such as cancer or inflammatory conditions. Sea cucumbers are one of the marine animals of the phylum Echinoderm. Many studies have shown that the sea cucumber contains antioxidants and anti‐cancer compounds. Chronic lymphocytic leukemia (CLL) is a disease characterized by the relentless accumulation of CD5 + B lymphocytes. CLL is the most common leukemia in adults, about 25–30% of all leukemias. In this study B lymphocytes and their mitochondria (cancerous and non‐cancerous) were obtained from peripheral blood of human subjects and B lymphocyte cytotoxicity assay, and caspase 3 activation along with mitochondrial upstream events of apoptosis signaling including reactive oxygen species (ROS) production, collapse of mitochondrial membrane potential (MMP) and mitochondrial swelling were determined following the addition of Holothuria parva extract to both cancerous and non‐cancerous B lymphocytes and their mitochondria. Our in vitro finding showed that mitochondrial ROS formation, MMP collapse, and mitochondrial swelling and cytochrome c release were significantly ( P < 0.05) increased after addition of different concentrations of H. parva only in cancerous BUT NOT normal non‐cancerous mitochondria. Consistently, different concentrations of H. parva significantly ( P < 0.05) increased cytotoxicity and caspase 3 activation only in cancerous BUT NOT normal non‐cancerous B lymphocytes. These results showed that H. parva methanolic extract has a selective mitochondria mediated apoptotic effect on chronic lymphocytic leukemia B lymphocytes hence may be promising in the future anticancer drug development for treatment of CLL. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1158–1169, 2017." @default.
• W2478374019 created "2016-08-23" @default.
• W2478374019 creator A5047460444 @default.
• W2478374019 creator A5047971818 @default.
• W2478374019 creator A5058158533 @default.
• W2478374019 creator A5059933401 @default.
• W2478374019 creator A5091027910 @default.
• W2478374019 creator A5091618884 @default.
• W2478374019 date "2016-07-12" @default.
• W2478374019 modified "2023-10-06" @default.
• W2478374019 title "Selective toxicity of persian gulf sea cucumber holothuria parva on human chronic lymphocytic leukemia b lymphocytes by direct mitochondrial targeting" @default.
• W2478374019 cites W1487157100 @default.
• W2478374019 cites W1505355747 @default.
• W2478374019 cites W1595640022 @default.
• W2478374019 cites W1603422612 @default.
• W2478374019 cites W1616121322 @default.
• W2478374019 cites W1816807490 @default.
• W2478374019 cites W1965694039 @default.
• W2478374019 cites W1972580596 @default.
• W2478374019 cites W1976417809 @default.
• W2478374019 cites W1981594548 @default.
• W2478374019 cites W1986568749 @default.
• W2478374019 cites W1993943341 @default.
• W2478374019 cites W1993986769 @default.
• W2478374019 cites W1999395328 @default.
• W2478374019 cites W2002926498 @default.
• W2478374019 cites W2017176789 @default.
• W2478374019 cites W2023295106 @default.
• W2478374019 cites W2031060436 @default.
• W2478374019 cites W2036240670 @default.
• W2478374019 cites W2036254586 @default.
• W2478374019 cites W2041992938 @default.
• W2478374019 cites W2043047320 @default.
• W2478374019 cites W2047337933 @default.
• W2478374019 cites W2062069198 @default.
• W2478374019 cites W2062253540 @default.
• W2478374019 cites W2062697756 @default.
• W2478374019 cites W2070764343 @default.
• W2478374019 cites W2072841925 @default.
• W2478374019 cites W2088569046 @default.
• W2478374019 cites W2113999599 @default.
• W2478374019 cites W2120751401 @default.
• W2478374019 cites W2137655819 @default.
• W2478374019 cites W2142099365 @default.
• W2478374019 cites W2142544985 @default.
• W2478374019 cites W2144277227 @default.
• W2478374019 cites W2156861743 @default.
• W2478374019 cites W2161726625 @default.
• W2478374019 cites W2214870473 @default.
• W2478374019 cites W2396005462 @default.
• W2478374019 doi "https://doi.org/10.1002/tox.22312" @default.
• W2478374019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27404045" @default.
• W2478374019 hasPublicationYear "2016" @default.
• W2478374019 type Work @default.
• W2478374019 sameAs 2478374019 @default.
• W2478374019 citedByCount "24" @default.
• W2478374019 countsByYear W24783740192017 @default.
• W2478374019 countsByYear W24783740192018 @default.
• W2478374019 countsByYear W24783740192019 @default.
• W2478374019 countsByYear W24783740192020 @default.
• W2478374019 countsByYear W24783740192021 @default.
• W2478374019 countsByYear W24783740192022 @default.
• W2478374019 crossrefType "journal-article" @default.
• W2478374019 hasAuthorship W2478374019A5047460444 @default.
• W2478374019 hasAuthorship W2478374019A5047971818 @default.
• W2478374019 hasAuthorship W2478374019A5058158533 @default.
• W2478374019 hasAuthorship W2478374019A5059933401 @default.
• W2478374019 hasAuthorship W2478374019A5091027910 @default.
• W2478374019 hasAuthorship W2478374019A5091618884 @default.
• W2478374019 hasConcept C109316439 @default.
• W2478374019 hasConcept C18903297 @default.
• W2478374019 hasConcept C190283241 @default.
• W2478374019 hasConcept C202751555 @default.
• W2478374019 hasConcept C203014093 @default.
• W2478374019 hasConcept C2776093933 @default.
• W2478374019 hasConcept C2777071529 @default.
• W2478374019 hasConcept C2777938653 @default.
• W2478374019 hasConcept C2778461978 @default.
• W2478374019 hasConcept C28859421 @default.
• W2478374019 hasConcept C29311851 @default.
• W2478374019 hasConcept C48349386 @default.
• W2478374019 hasConcept C55493867 @default.
• W2478374019 hasConcept C86803240 @default.
• W2478374019 hasConcept C98274493 @default.
• W2478374019 hasConceptScore W2478374019C109316439 @default.
• W2478374019 hasConceptScore W2478374019C18903297 @default.
• W2478374019 hasConceptScore W2478374019C190283241 @default.
• W2478374019 hasConceptScore W2478374019C202751555 @default.
• W2478374019 hasConceptScore W2478374019C203014093 @default.
• W2478374019 hasConceptScore W2478374019C2776093933 @default.
• W2478374019 hasConceptScore W2478374019C2777071529 @default.
• W2478374019 hasConceptScore W2478374019C2777938653 @default.
• W2478374019 hasConceptScore W2478374019C2778461978 @default.
• W2478374019 hasConceptScore W2478374019C28859421 @default.
• W2478374019 hasConceptScore W2478374019C29311851 @default.
• W2478374019 hasConceptScore W2478374019C48349386 @default.
• W2478374019 hasConceptScore W2478374019C55493867 @default.
• W2478374019 hasConceptScore W2478374019C86803240 @default.

• next