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- W2478492092 endingPage "97" @default.
- W2478492092 startingPage "69" @default.
- W2478492092 abstract "Eukaryotes contain a diverse tapestry of specialized metabolites, many of which are of significant pharmaceutical and industrial importance to humans. Nevertheless, exploration of specialized metabolic pathways underlying specific chemical traits in nonmodel eukaryotic organisms has been technically challenging and historically lagged behind that of the bacterial systems. Recent advances in genomics, metabolomics, phylogenomics, and synthetic biology now enable a new workflow for interrogating unknown specialized metabolic systems in nonmodel eukaryotic hosts with greater efficiency and mechanistic depth. This chapter delineates such workflow by providing a collection of state-of-the-art approaches and tools, ranging from multiomics-guided candidate gene identification to in vitro and in vivo functional and structural characterization of specialized metabolic enzymes. As already demonstrated by several recent studies, this new workflow opens up a gateway into the largely untapped world of natural product biochemistry in eukaryotes." @default.
- W2478492092 created "2016-08-23" @default.
- W2478492092 creator A5038549035 @default.
- W2478492092 creator A5067476384 @default.
- W2478492092 creator A5074471537 @default.
- W2478492092 date "2016-01-01" @default.
- W2478492092 modified "2023-09-27" @default.
- W2478492092 title "A Workflow for Studying Specialized Metabolism in Nonmodel Eukaryotic Organisms" @default.
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