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- W2478516668 abstract "Sodium glucose co‒transporter 2（SGLT2）inhibitor lowers blood pressure（BP）as well as blood glucose through suppression of kidney glucose reabsorption. We investigated whether the SGLT2 inhibitor dapagliflozin（DAPA）improves BP variability and whether DAPA with renin‒angiotensin system（RAS）inhibitor effectively decreases BP in Japanese patients with type 2 diabetes mellitus and hypertension. In Twenty‒four eligible patients treated with DAPA 5 mg/day for 12 weeks, 24‒hour BP was determined by ambulatory BP monitoring, visceral fat mass was assessed by a dual‒impedance method and glucose metabolism was monitored. After DAPA treatment, systolic BP（SBP）in 24‒hour and nighttime were significantly decreased and SBP in daytime showed marginally‒significant decrease, and BP variability was improved with reversal of the riser type （nighttime BP＞daytime BP）in three patients. In the RAS‒inhibitor‒treated group（n＝16）, the 24‒hour BP was decreased, but not in the untreated group（n＝8）. Fasting plasma glucose, HbA1c and visceral fat area were significantly decreased in both groups, and there was no difference in these parameters between the groups. Serum insulin level was reduced only in the RAS‒inhibitor‒treated group. Adverse drug reactions occurred in two patients. DAPA improved the 24‒hour BP, circadian variability of BP, body composition and metabolic parameters. These improvements were notable in those who underwent combined therapy with DAPA and RAS inhibitors. Combined therapy with SGLT2 and RAS inhibitors may be useful in Japanese patients with type 2 diabetes mellitus and hypertension." @default.
- W2478516668 created "2016-08-23" @default.
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- W2478516668 date "2016-01-01" @default.
- W2478516668 modified "2023-09-23" @default.
- W2478516668 title "Dapagliflozin, an SGLT2 Inhibitor, Enhances Antihypertensive and Glucose Metabolism Effects of Renin‒Angiotensin System Inhibitor in Japanese Patients with Type 2 Diabetes Mellitus and Hypertension" @default.
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