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- W2478555722 abstract "Myxovirus resistance proteins represent a family of interferon-induced restriction factors of the innate and adaptive immune system. Human MxB acts as a novel restriction factor with antiviral activity against a range of HIV-1 and other retroviruses mainly by inhibiting the uncoating process after reverse transcription but prior to integration. Based on published data and conservation analysis, we propose a novel hypothesis, in which MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. Insights into the mechanistic basis of structural and functional characteristics of MxB will greatly advance our understanding of MxB." @default.
- W2478555722 created "2016-08-23" @default.
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- W2478555722 date "2016-08-01" @default.
- W2478555722 modified "2023-09-27" @default.
- W2478555722 title "Mx oligomer: a novel capsid pattern sensor?" @default.
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- W2478555722 doi "https://doi.org/10.2217/fmb-2016-0004" @default.
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