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- W2478650926 abstract "Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. MicroRNAs (miRNAs) play vital roles in virus-host interactions by regulating the expression of viral or host gene at posttranscriptional level. Our previous research showed that PRRSV infection down-regulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, and overexpression of HO-1 inhibits PRRSV replication. In this study, we demonstrate that host miRNA miR-22 can downregulate HO-1 expression by directly targeting its 3' untranslated region. Suppression of HO-1 expression by miR-22 facilitates PRRSV replication. This work suggests that PRRSV may utilize cellular miRNA to modify antiviral host factor expression, enabling viral replication, which not only provides new insights into virus-host interactions during PRRSV infection, but also suggests potential therapies for PRRSV infection." @default.
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- W2478650926 date "2016-08-01" @default.
- W2478650926 modified "2023-10-16" @default.
- W2478650926 title "MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1" @default.
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- W2478650926 doi "https://doi.org/10.1016/j.vetmic.2016.07.026" @default.
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