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- W2478691700 endingPage "3071" @default.
- W2478691700 startingPage "3065" @default.
- W2478691700 abstract "The serious consequences of influenza infection during pregnancy have been recognized for almost a century. In this article, we reviewed the evidence on the immunogenicity, safety and impact of maternal influenza immunization for both mother and child. After vaccination, pregnant women have similar protective titers of anti-influenza antibodies as non-pregnant women, demonstrating that pregnancy does not alter the trivalent inactivated influenza vaccine immune response. Studies from the United States, Europe and resource-constrained regions demonstrate that maternal vaccination is associated with increased anti-influenza antibody concentrations and protection in the newborn child as well as the immunized mother. Given the acceptable safety profile of influenza vaccines and the World Health Organization's recommendation for its use in pregnant women, maternal vaccination with inactivated influenza vaccine is a cost-effective approach to decrease influenza disease in newborns. However, as seen for influenza immunization in the elderly, the protective efficacy of current inactivated vaccines in protection of newborns is 50% at best, indicating significant room for vaccine improvement, which could potentially be achieved by addition of a safe and effective adjuvant. Thus, global deployment of inactivated influenza immunization during pregnancy would have substantial and measurable health benefits for mothers and their newborns." @default.
- W2478691700 created "2016-08-23" @default.
- W2478691700 creator A5033839836 @default.
- W2478691700 creator A5070788647 @default.
- W2478691700 creator A5079311523 @default.
- W2478691700 creator A5085118064 @default.
- W2478691700 date "2016-08-05" @default.
- W2478691700 modified "2023-10-12" @default.
- W2478691700 title "Influenza immunization during pregnancy: Benefits for mother and infant" @default.
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