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- W2478964482 abstract "Background: Pharmacovigilance is an important tool to gather real-life information on effectiveness and adverse effects of drugs. Therefore, post-marketing study can lead to new therapeutic insights or even market withdrawal. In September 2004, rofecoxib was withdrawn from the market for reasons of serious cardiovascular safety. Objectives: Our objective was to examine the effect of withdrawal rofecoxib on the prescription of overall NSAIDs, coxibs and traditional NSAIDs (t-NSAIDs). Methods: A retrospective cohort study was conducted using pharmacy dispensing data from IADB.nl (50 pharmacies), covering a Dutch population of 500,000 subjects. The study cohort consists of patients who filed at least one prescription NSAIDs 6 month before and after 30th September 2004. The control cohort was defined 12 months prior to study cohort with setting a hypothetical date at 30th September 2003. Results: After market withdrawal of rofecoxib, no difference was found in overall number of NSAID users in the study cohort (prevalence 51.4 and 50.4 per 1000 population before and after withdrawal, respectively). For the control cohort, this pattern was essentially similar (55.9 and 55.0 per 1000 population, respectively). The prevalence of coxib users decreased significantly from 178 to 89 among 1000 NSAIDs users before versus after withdrawal. The prevalence of coxib users increased significantly from 110 to 142 among 1000 NSAID users in the control cohort. The withdrawal of rofecoxib led to increased use of t-NSAIDs (from 83% to 92%) as prescribers switched to this alternative agent. In contrast, this trend was not found in control cohort. Conclusions: Market withdrawal of rofecoxib did not affect overall use of NSAIDs. However, a significant decline of coxib use was found led to an increased proportion of t- NSAID users. Further results will be presented on switching patterns with focus on concomitant use of proton-pumpinhibitors for gastrointestinal protection." @default.
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- W2478964482 date "2010-08-01" @default.
- W2478964482 modified "2023-09-26" @default.
- W2478964482 title "The impact of withdrawal rofecoxib on NSAIDs utilization" @default.
- W2478964482 hasPublicationYear "2010" @default.
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