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- W2478991725 abstract "Publisher Summary This chapter reviews vertebrate α-synuclein transgenic mouse models which have led to substantial advances in understanding the role of α-synuclein in pathogenic processes that are relevant to Parkinson's disease (PD). Mutations in the gene coding for leucine rich repeat kinase-2 (LRRK2) also lead to autosomal-dominant PD. LRRK2 is a large protein containing multiple functional domains including a GTPase and kinase domain. Of the various α-synuclein transgenic mice that have been generated over the years, the models using the murine Thy-1 promoter and the murine prion promoter recapitulate most if not all the pathogenic features of PD, except for degeneration of dopamine neurons. Transgenic mice overexpressing α-synuclein under either promoter develop α-synucleinopathy in neurons and overlapping brain regions with predominate pathology in spinal motor neurons, deep cerebellar nuclei, pontine reticular nuclei and the red nucleus. The neuronal populations are particularly vulnerable to α-synuclein-induced neurodegeneration in mice. It is suggested that the α-synuclein transgenic models can be used to explore the molecular basis of cell death induced by α-synuclein." @default.
- W2478991725 created "2016-08-23" @default.
- W2478991725 creator A5021759485 @default.
- W2478991725 creator A5025568267 @default.
- W2478991725 creator A5080005941 @default.
- W2478991725 date "2008-01-01" @default.
- W2478991725 modified "2023-10-17" @default.
- W2478991725 title "Genetic Models of Familial Parkinson's Disease" @default.
- W2478991725 cites W1237068170 @default.
- W2478991725 cites W1487645896 @default.
- W2478991725 cites W1496790952 @default.
- W2478991725 cites W1516672767 @default.
- W2478991725 cites W1527671059 @default.
- W2478991725 cites W1550876205 @default.
- W2478991725 cites W1561951468 @default.
- W2478991725 cites W1572679174 @default.
- W2478991725 cites W1618846043 @default.
- W2478991725 cites W1757845542 @default.
- W2478991725 cites W1877873625 @default.
- W2478991725 cites W191741448 @default.
- W2478991725 cites W1952583315 @default.
- W2478991725 cites W1965111978 @default.
- W2478991725 cites W1965778124 @default.
- W2478991725 cites W1967603366 @default.
- W2478991725 cites W1968800738 @default.
- W2478991725 cites W1970687029 @default.
- W2478991725 cites W1971389338 @default.
- W2478991725 cites W1976148085 @default.
- W2478991725 cites W1980110509 @default.
- W2478991725 cites W1983951782 @default.
- W2478991725 cites W1986118996 @default.
- W2478991725 cites W1986188355 @default.
- W2478991725 cites W1986216002 @default.
- W2478991725 cites W1986628169 @default.
- W2478991725 cites W1987041769 @default.
- W2478991725 cites W1999893655 @default.
- W2478991725 cites W2002506451 @default.
- W2478991725 cites W2006875797 @default.
- W2478991725 cites W2009021103 @default.
- W2478991725 cites W2011332000 @default.
- W2478991725 cites W2011894009 @default.
- W2478991725 cites W2021224973 @default.
- W2478991725 cites W2022116515 @default.
- W2478991725 cites W2024281265 @default.
- W2478991725 cites W2025842100 @default.
- W2478991725 cites W2025922492 @default.
- W2478991725 cites W2026841498 @default.
- W2478991725 cites W2028796406 @default.
- W2478991725 cites W2031031932 @default.
- W2478991725 cites W2032481706 @default.
- W2478991725 cites W2039007685 @default.
- W2478991725 cites W2046964897 @default.
- W2478991725 cites W2050786534 @default.
- W2478991725 cites W2050849483 @default.
- W2478991725 cites W2055124287 @default.
- W2478991725 cites W2056823686 @default.
- W2478991725 cites W2063127941 @default.
- W2478991725 cites W2064132534 @default.
- W2478991725 cites W2065060908 @default.
- W2478991725 cites W2066594212 @default.
- W2478991725 cites W2066929651 @default.
- W2478991725 cites W2069479107 @default.
- W2478991725 cites W2073449985 @default.
- W2478991725 cites W2075714285 @default.
- W2478991725 cites W2082214922 @default.
- W2478991725 cites W2084910880 @default.
- W2478991725 cites W2088962120 @default.
- W2478991725 cites W2091265794 @default.
- W2478991725 cites W2092791231 @default.
- W2478991725 cites W2095338669 @default.
- W2478991725 cites W2100025688 @default.
- W2478991725 cites W2100300726 @default.
- W2478991725 cites W2100894616 @default.
- W2478991725 cites W2101602982 @default.
- W2478991725 cites W2104382960 @default.
- W2478991725 cites W2114881821 @default.
- W2478991725 cites W2123133951 @default.
- W2478991725 cites W2123184492 @default.
- W2478991725 cites W2123431154 @default.
- W2478991725 cites W2124405216 @default.
- W2478991725 cites W2126549314 @default.
- W2478991725 cites W2129698492 @default.
- W2478991725 cites W2130792966 @default.
- W2478991725 cites W2130909417 @default.
- W2478991725 cites W2131256783 @default.
- W2478991725 cites W2131710583 @default.
- W2478991725 cites W2132967706 @default.
- W2478991725 cites W2133407217 @default.
- W2478991725 cites W2134272142 @default.
- W2478991725 cites W2136216054 @default.
- W2478991725 cites W2136388422 @default.
- W2478991725 cites W2139369185 @default.
- W2478991725 cites W2142286857 @default.
- W2478991725 cites W2142460292 @default.
- W2478991725 cites W2143161560 @default.
- W2478991725 cites W2148869194 @default.
- W2478991725 cites W2150656456 @default.
- W2478991725 cites W2151199043 @default.