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- W2479009306 abstract "There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. Here, we present a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system's dynamics. We present example pathway models that illustrate of the power of approach to depict a diverse range of systems." @default.
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- W2479009306 date "2016-08-10" @default.
- W2479009306 modified "2023-09-30" @default.
- W2479009306 title "Modelling the Structure and Dynamics of Biological Pathways" @default.
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- W2479009306 doi "https://doi.org/10.1371/journal.pbio.1002530" @default.
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