Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479133057> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2479133057 abstract "Abstract : The main objective of this DOD-supported project is to identify and develop novel therapeutics to target the undifferentiated (PSA-/lo), castration-resistant PCSCs. We proposed to achieve this objective with two Specific Aims: 1) To perform phage display library (PDL) screening in PSA-/lo PCa cells to identify PCSC-specific homing peptides; and 2) To perform unbiased drug library screening to identify novel PCSC-targeting chemicals. In the past year, we have made good progress in accomplishing the goals for both Aims. For Specific Aim 1, we have further characterized the JRM2 peptide. For Specific Aim 2, we have finished a targeted library screening to identify several compounds that could sensitize the AR-PSA- LNCaP cells. We have also started screening our UNIQUE PSA-/lo CRPC cells against a Protein Kinase Inhibitor Collection that contains 750 compounds that target 140 kinases. In the second year, we shall continue several experiments in both Aims, especially testing the in vitro and in vivo cytotoxicities of the conjugated JRM2 peptide and finishing up screening and validating the kinase inhibitor library screening." @default.
- W2479133057 created "2016-08-23" @default.
- W2479133057 creator A5083990383 @default.
- W2479133057 date "2015-10-01" @default.
- W2479133057 modified "2023-09-23" @default.
- W2479133057 title "Developing Novel Therapeutics Targeting Undifferentiated and Castration-Resistant Prostate Cancer Stem Cells" @default.
- W2479133057 hasPublicationYear "2015" @default.
- W2479133057 type Work @default.
- W2479133057 sameAs 2479133057 @default.
- W2479133057 citedByCount "0" @default.
- W2479133057 crossrefType "journal-article" @default.
- W2479133057 hasAuthorship W2479133057A5083990383 @default.
- W2479133057 hasConcept C104317684 @default.
- W2479133057 hasConcept C121608353 @default.
- W2479133057 hasConcept C126322002 @default.
- W2479133057 hasConcept C143998085 @default.
- W2479133057 hasConcept C151872237 @default.
- W2479133057 hasConcept C159654299 @default.
- W2479133057 hasConcept C167625842 @default.
- W2479133057 hasConcept C184235292 @default.
- W2479133057 hasConcept C186268636 @default.
- W2479133057 hasConcept C18903297 @default.
- W2479133057 hasConcept C203014093 @default.
- W2479133057 hasConcept C2776471321 @default.
- W2479133057 hasConcept C2779723316 @default.
- W2479133057 hasConcept C2780192828 @default.
- W2479133057 hasConcept C502942594 @default.
- W2479133057 hasConcept C55493867 @default.
- W2479133057 hasConcept C60644358 @default.
- W2479133057 hasConcept C70721500 @default.
- W2479133057 hasConcept C71924100 @default.
- W2479133057 hasConcept C74187038 @default.
- W2479133057 hasConcept C86803240 @default.
- W2479133057 hasConceptScore W2479133057C104317684 @default.
- W2479133057 hasConceptScore W2479133057C121608353 @default.
- W2479133057 hasConceptScore W2479133057C126322002 @default.
- W2479133057 hasConceptScore W2479133057C143998085 @default.
- W2479133057 hasConceptScore W2479133057C151872237 @default.
- W2479133057 hasConceptScore W2479133057C159654299 @default.
- W2479133057 hasConceptScore W2479133057C167625842 @default.
- W2479133057 hasConceptScore W2479133057C184235292 @default.
- W2479133057 hasConceptScore W2479133057C186268636 @default.
- W2479133057 hasConceptScore W2479133057C18903297 @default.
- W2479133057 hasConceptScore W2479133057C203014093 @default.
- W2479133057 hasConceptScore W2479133057C2776471321 @default.
- W2479133057 hasConceptScore W2479133057C2779723316 @default.
- W2479133057 hasConceptScore W2479133057C2780192828 @default.
- W2479133057 hasConceptScore W2479133057C502942594 @default.
- W2479133057 hasConceptScore W2479133057C55493867 @default.
- W2479133057 hasConceptScore W2479133057C60644358 @default.
- W2479133057 hasConceptScore W2479133057C70721500 @default.
- W2479133057 hasConceptScore W2479133057C71924100 @default.
- W2479133057 hasConceptScore W2479133057C74187038 @default.
- W2479133057 hasConceptScore W2479133057C86803240 @default.
- W2479133057 hasLocation W24791330571 @default.
- W2479133057 hasOpenAccess W2479133057 @default.
- W2479133057 hasPrimaryLocation W24791330571 @default.
- W2479133057 hasRelatedWork W1492065209 @default.
- W2479133057 hasRelatedWork W1524663114 @default.
- W2479133057 hasRelatedWork W1974216005 @default.
- W2479133057 hasRelatedWork W2015356618 @default.
- W2479133057 hasRelatedWork W2019017694 @default.
- W2479133057 hasRelatedWork W2044173055 @default.
- W2479133057 hasRelatedWork W2074188115 @default.
- W2479133057 hasRelatedWork W2077269148 @default.
- W2479133057 hasRelatedWork W211666145 @default.
- W2479133057 hasRelatedWork W2169063134 @default.
- W2479133057 hasRelatedWork W2283014176 @default.
- W2479133057 hasRelatedWork W2319778858 @default.
- W2479133057 hasRelatedWork W2341087013 @default.
- W2479133057 hasRelatedWork W2767510097 @default.
- W2479133057 hasRelatedWork W294841294 @default.
- W2479133057 hasRelatedWork W3025666246 @default.
- W2479133057 hasRelatedWork W3120280136 @default.
- W2479133057 hasRelatedWork W1490081512 @default.
- W2479133057 hasRelatedWork W1602312745 @default.
- W2479133057 hasRelatedWork W3140761970 @default.
- W2479133057 isParatext "false" @default.
- W2479133057 isRetracted "false" @default.
- W2479133057 magId "2479133057" @default.
- W2479133057 workType "article" @default.