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- W2479138879 abstract "Background: Endometrial cancer (EmCa) Type I is estrogen dependent whereas Type II is estrogen independent and usually associated with endometrial atrophy. Type II is the more aggressive form with a poor prognosis. Obesity is a growing epidemic and is a major risk factor for EmCa. African-American women have higher incidence of obesity, and are more likely to die from EmCa even though the risk of developing EmCa is lower in Caucasian women. Obesity is characterized by high serum leptin levels, which are associated cancer incidence, metastasis and poor prognosis. Leptin9s effects in breast cancer are related to the induction of a crosstalk between Notch, IL-1 and leptin (NILCO). It is hypothesize that there is a positive correlation between Type II EmCa, NILCO and obesity. Methods: The expression of NILCO components was determined by immunohistochemistry in Type I vs Type II EmCa biopsies from obese African American and lean tissue array from Chinese patients. Additionally, the effects of leptin on cell proliferation and NILCO expression were determined in cell lines derived from Type I and Type II EmCa (Ishikawa, Hec1a, An3ca and KLE), respectively. Results: NILCO components were expressed higher in Type II EmCa, more advanced disease, and correlated with obesity. Also, leptin induction of NILCO was more prominent in Type II EmCa cells. Conclusions: Obesity signals (i.e., leptin) could induce NILCO in EmCa. Leptin could play a significant role in EmCa progression, especially in Type II EmCa. Therefore, NILCO could represent a novel biomarker for the more aggressive Type II EmCa. These observations could be more relevant for obese EmCa patients. Citation Format: Danielle Daley-Brown, Gabriela Oprea-Ilies, Kiara T. Vann, Roland Pattillo, James Lillard, Ruben Rene Gonzalez-Perez. Leptin-induced NILCO in endometrial cancer is linked to obesity. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1008." @default.
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- W2479138879 date "2016-07-15" @default.
- W2479138879 modified "2023-09-26" @default.
- W2479138879 title "Abstract 1008: Leptin-induced NILCO in endometrial cancer is linked to obesity" @default.
- W2479138879 doi "https://doi.org/10.1158/1538-7445.am2016-1008" @default.
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