Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479218368> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2479218368 abstract "The Sm-like proteins (also known as Lsm proteins) are ubiquitous in nature and exist as hexa or heptameric RNA binding complexes. They are characterized by the presence of the Sm-domain. The Lsm1 through Lsm7 proteins are highly conserved in eukaryotes and they form a hetero-octameric complex together with the protein Pat1. The Lsm1-7-Pat1 complex plays a key role in mRNA decapping and 3'-end protection and therefore is required for normal mRNA decay rates in vivo. Lsm1 is a key subunit that is critical for the unique RNA binding properties of this complex. We showed earlier that unlike most Sm-like proteins, Lsm1 uniquely requires both its Sm domain and its C-terminal extension to contribute to the function of the Lsm1-7-Pat1 complex and that the C-terminal segment can associate with the rest of the complex and support the function even in trans. The studies presented here identify a set of residues at the very C-terminal end of Lsm1 to be functionally important and suggest that these residues support the function of the Lsm1-7-Pat1 complex by facilitating RNA binding either directly or indirectly." @default.
- W2479218368 created "2016-08-23" @default.
- W2479218368 creator A5001164205 @default.
- W2479218368 creator A5038498972 @default.
- W2479218368 creator A5061861167 @default.
- W2479218368 date "2016-07-19" @default.
- W2479218368 modified "2023-09-26" @default.
- W2479218368 title "Mutagenic Analysis of the C-Terminal Extension of Lsm1" @default.
- W2479218368 cites W1513568483 @default.
- W2479218368 cites W1938159926 @default.
- W2479218368 cites W1970626969 @default.
- W2479218368 cites W1978810041 @default.
- W2479218368 cites W1979566118 @default.
- W2479218368 cites W1990214042 @default.
- W2479218368 cites W1997279341 @default.
- W2479218368 cites W2018431872 @default.
- W2479218368 cites W2035398832 @default.
- W2479218368 cites W2058985658 @default.
- W2479218368 cites W2069208087 @default.
- W2479218368 cites W2082658854 @default.
- W2479218368 cites W2100361875 @default.
- W2479218368 cites W2104496647 @default.
- W2479218368 cites W2117549506 @default.
- W2479218368 cites W2117764830 @default.
- W2479218368 cites W2121770428 @default.
- W2479218368 cites W2124223800 @default.
- W2479218368 cites W2133929311 @default.
- W2479218368 cites W2136987752 @default.
- W2479218368 cites W2139340906 @default.
- W2479218368 cites W2150799390 @default.
- W2479218368 cites W2153114644 @default.
- W2479218368 cites W2167144689 @default.
- W2479218368 doi "https://doi.org/10.1371/journal.pone.0158876" @default.
- W2479218368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4951014" @default.
- W2479218368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27434131" @default.
- W2479218368 hasPublicationYear "2016" @default.
- W2479218368 type Work @default.
- W2479218368 sameAs 2479218368 @default.
- W2479218368 citedByCount "0" @default.
- W2479218368 crossrefType "journal-article" @default.
- W2479218368 hasAuthorship W2479218368A5001164205 @default.
- W2479218368 hasAuthorship W2479218368A5038498972 @default.
- W2479218368 hasAuthorship W2479218368A5061861167 @default.
- W2479218368 hasBestOaLocation W24792183681 @default.
- W2479218368 hasConcept C104317684 @default.
- W2479218368 hasConcept C105580179 @default.
- W2479218368 hasConcept C41282012 @default.
- W2479218368 hasConcept C54355233 @default.
- W2479218368 hasConcept C67705224 @default.
- W2479218368 hasConcept C70721500 @default.
- W2479218368 hasConcept C86803240 @default.
- W2479218368 hasConcept C95444343 @default.
- W2479218368 hasConceptScore W2479218368C104317684 @default.
- W2479218368 hasConceptScore W2479218368C105580179 @default.
- W2479218368 hasConceptScore W2479218368C41282012 @default.
- W2479218368 hasConceptScore W2479218368C54355233 @default.
- W2479218368 hasConceptScore W2479218368C67705224 @default.
- W2479218368 hasConceptScore W2479218368C70721500 @default.
- W2479218368 hasConceptScore W2479218368C86803240 @default.
- W2479218368 hasConceptScore W2479218368C95444343 @default.
- W2479218368 hasLocation W24792183681 @default.
- W2479218368 hasLocation W24792183682 @default.
- W2479218368 hasLocation W24792183683 @default.
- W2479218368 hasLocation W24792183684 @default.
- W2479218368 hasLocation W24792183685 @default.
- W2479218368 hasLocation W24792183686 @default.
- W2479218368 hasOpenAccess W2479218368 @default.
- W2479218368 hasPrimaryLocation W24792183681 @default.
- W2479218368 hasRelatedWork W1948969711 @default.
- W2479218368 hasRelatedWork W2014841548 @default.
- W2479218368 hasRelatedWork W2034064568 @default.
- W2479218368 hasRelatedWork W2048655220 @default.
- W2479218368 hasRelatedWork W2065739720 @default.
- W2479218368 hasRelatedWork W2076355407 @default.
- W2479218368 hasRelatedWork W2092458834 @default.
- W2479218368 hasRelatedWork W2094501123 @default.
- W2479218368 hasRelatedWork W2096603665 @default.
- W2479218368 hasRelatedWork W2100361875 @default.
- W2479218368 hasRelatedWork W2125323012 @default.
- W2479218368 hasRelatedWork W2128372739 @default.
- W2479218368 hasRelatedWork W2135419864 @default.
- W2479218368 hasRelatedWork W2136987752 @default.
- W2479218368 hasRelatedWork W2142068708 @default.
- W2479218368 hasRelatedWork W2166529547 @default.
- W2479218368 hasRelatedWork W2329808975 @default.
- W2479218368 hasRelatedWork W2333911605 @default.
- W2479218368 hasRelatedWork W3020174889 @default.
- W2479218368 hasRelatedWork W3179979039 @default.
- W2479218368 isParatext "false" @default.
- W2479218368 isRetracted "false" @default.
- W2479218368 magId "2479218368" @default.
- W2479218368 workType "article" @default.