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- W2479285308 abstract "Cancer progression is generally described in terms of accumulated genetic alterations and ensuing changes in cell properties. However, intermediary modifications are involved in the establishment of cancer cell phenotypes, at different levels of nuclear organization: DNA damages and their structural consequences, epigenetic modifications and their impact on chromatin architecture, changes in chromosome 3D organization. We review some of these alterations with a focus on their physical aspects. The challenge is to understand the multiscale interplay between generic physical mechanisms and specific biological factors in cancer cells. We argue that such an interdisciplinary perspective offers a novel viewpoint on cancer progression, early diagnosis and possibly therapeutic targets." @default.
- W2479285308 created "2016-08-23" @default.
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- W2479285308 date "2016-01-01" @default.
- W2479285308 modified "2023-10-18" @default.
- W2479285308 title "The physics of cancer: The role of epigenetics and chromosome conformation in cancer progression" @default.
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- W2479285308 doi "https://doi.org/10.1063/1.4960270" @default.
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