Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479303073> ?p ?o ?g. }
- W2479303073 endingPage "6347" @default.
- W2479303073 startingPage "6340" @default.
- W2479303073 abstract "Abstract Co-culturing the fungal endophyte Chaetomium sp. with the bacterium Bacillus subtilis on solid rice medium resulted in an up to 8.3-fold increase in the accumulation of constitutively present metabolites that included a 1:1 mixture of 3- and 4-hydroxybenzoic acid methyl esters (1 and 2, respectively), and the polyketides acremonisol A (3), SB236050 (4), and SB238569 (5). In addition, seven compounds including isosulochrin (6), protocatechuic acid methyl ester (7), as well as five new natural products (8–12) were detected in the co-cultures, but not in axenic fungal cultures. Treatment of Chaetomium sp. with the epigenetic modifier suberoylanilide hydroxamic acid or 5-azacytidine resulted in an enhanced accumulation of 6, which was likewise detected during co-culture. Compound 5 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 1 μM, as well as weak antibacterial activity against B. subtilis with an MIC value of 53 μM." @default.
- W2479303073 created "2016-08-23" @default.
- W2479303073 creator A5002070741 @default.
- W2479303073 creator A5005983756 @default.
- W2479303073 creator A5015298659 @default.
- W2479303073 creator A5019127771 @default.
- W2479303073 creator A5024132353 @default.
- W2479303073 creator A5040178005 @default.
- W2479303073 creator A5081806586 @default.
- W2479303073 date "2016-10-01" @default.
- W2479303073 modified "2023-10-06" @default.
- W2479303073 title "Inducing secondary metabolite production by the endophytic fungus Chaetomium sp. through fungal–bacterial co-culture and epigenetic modification" @default.
- W2479303073 cites W1225182422 @default.
- W2479303073 cites W1678194650 @default.
- W2479303073 cites W1701148520 @default.
- W2479303073 cites W1856362670 @default.
- W2479303073 cites W1966929882 @default.
- W2479303073 cites W1966988075 @default.
- W2479303073 cites W1980713037 @default.
- W2479303073 cites W1988815096 @default.
- W2479303073 cites W1996255717 @default.
- W2479303073 cites W2005933242 @default.
- W2479303073 cites W2015259121 @default.
- W2479303073 cites W2019902127 @default.
- W2479303073 cites W2023822229 @default.
- W2479303073 cites W2027197117 @default.
- W2479303073 cites W2032925644 @default.
- W2479303073 cites W2037594947 @default.
- W2479303073 cites W2044531558 @default.
- W2479303073 cites W2044591029 @default.
- W2479303073 cites W2070570660 @default.
- W2479303073 cites W2074457663 @default.
- W2479303073 cites W2084248712 @default.
- W2479303073 cites W2086416477 @default.
- W2479303073 cites W2089832682 @default.
- W2479303073 cites W2091532937 @default.
- W2479303073 cites W2099556958 @default.
- W2479303073 cites W2109478474 @default.
- W2479303073 cites W2117722841 @default.
- W2479303073 cites W2133206289 @default.
- W2479303073 cites W2142383147 @default.
- W2479303073 cites W2144217762 @default.
- W2479303073 cites W2158612142 @default.
- W2479303073 cites W2162406580 @default.
- W2479303073 cites W2436067889 @default.
- W2479303073 cites W2950402849 @default.
- W2479303073 doi "https://doi.org/10.1016/j.tet.2016.08.022" @default.
- W2479303073 hasPublicationYear "2016" @default.
- W2479303073 type Work @default.
- W2479303073 sameAs 2479303073 @default.
- W2479303073 citedByCount "78" @default.
- W2479303073 countsByYear W24793030732017 @default.
- W2479303073 countsByYear W24793030732018 @default.
- W2479303073 countsByYear W24793030732019 @default.
- W2479303073 countsByYear W24793030732020 @default.
- W2479303073 countsByYear W24793030732021 @default.
- W2479303073 countsByYear W24793030732022 @default.
- W2479303073 countsByYear W24793030732023 @default.
- W2479303073 crossrefType "journal-article" @default.
- W2479303073 hasAuthorship W2479303073A5002070741 @default.
- W2479303073 hasAuthorship W2479303073A5005983756 @default.
- W2479303073 hasAuthorship W2479303073A5015298659 @default.
- W2479303073 hasAuthorship W2479303073A5019127771 @default.
- W2479303073 hasAuthorship W2479303073A5024132353 @default.
- W2479303073 hasAuthorship W2479303073A5040178005 @default.
- W2479303073 hasAuthorship W2479303073A5081806586 @default.
- W2479303073 hasConcept C104317684 @default.
- W2479303073 hasConcept C185592680 @default.
- W2479303073 hasConcept C2777347573 @default.
- W2479303073 hasConcept C2777477808 @default.
- W2479303073 hasConcept C2777484150 @default.
- W2479303073 hasConcept C2778577587 @default.
- W2479303073 hasConcept C2779678110 @default.
- W2479303073 hasConcept C2910378060 @default.
- W2479303073 hasConcept C31903555 @default.
- W2479303073 hasConcept C55493867 @default.
- W2479303073 hasConcept C59822182 @default.
- W2479303073 hasConcept C86803240 @default.
- W2479303073 hasConcept C89423630 @default.
- W2479303073 hasConcept C89638049 @default.
- W2479303073 hasConceptScore W2479303073C104317684 @default.
- W2479303073 hasConceptScore W2479303073C185592680 @default.
- W2479303073 hasConceptScore W2479303073C2777347573 @default.
- W2479303073 hasConceptScore W2479303073C2777477808 @default.
- W2479303073 hasConceptScore W2479303073C2777484150 @default.
- W2479303073 hasConceptScore W2479303073C2778577587 @default.
- W2479303073 hasConceptScore W2479303073C2779678110 @default.
- W2479303073 hasConceptScore W2479303073C2910378060 @default.
- W2479303073 hasConceptScore W2479303073C31903555 @default.
- W2479303073 hasConceptScore W2479303073C55493867 @default.
- W2479303073 hasConceptScore W2479303073C59822182 @default.
- W2479303073 hasConceptScore W2479303073C86803240 @default.
- W2479303073 hasConceptScore W2479303073C89423630 @default.
- W2479303073 hasConceptScore W2479303073C89638049 @default.
- W2479303073 hasFunder F4320320875 @default.
- W2479303073 hasIssue "41" @default.
- W2479303073 hasLocation W24793030731 @default.
- W2479303073 hasOpenAccess W2479303073 @default.