Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479450422> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2479450422 endingPage "71" @default.
- W2479450422 startingPage "50" @default.
- W2479450422 abstract "Recombinant antibody technology and computational modeling make it possible to deduce intermolecular interactions between antibody and antigen, and genetically alter antibody affinity and selectivity. A recombinant antibody (Fab 481.1) that competitively bound diuron was cloned from a diuron-specific hybridoma. Fabs that bound diuron hapten conjugate but not free diuron were also selected from semi-synthetic combinatorial antibody libraries. A computer model of Fab 481.1 was constructed based on structural homology with known antibodies. The steps in the modeling process and subsequent refinements are described. From the model we identified a putative diuron binding site and the atomic interactions of diuron with amino acids in the site. Inferences from the model will be tested by site-directed mutagenesis to produce Fabs with altered binding properties." @default.
- W2479450422 created "2016-08-23" @default.
- W2479450422 creator A5001501679 @default.
- W2479450422 creator A5039016384 @default.
- W2479450422 creator A5051750612 @default.
- W2479450422 creator A5075428131 @default.
- W2479450422 creator A5083384131 @default.
- W2479450422 date "1995-03-23" @default.
- W2479450422 modified "2023-10-06" @default.
- W2479450422 title "Recombinant Antibodies to Diuron" @default.
- W2479450422 doi "https://doi.org/10.1021/bk-1995-0586.ch004" @default.
- W2479450422 hasPublicationYear "1995" @default.
- W2479450422 type Work @default.
- W2479450422 sameAs 2479450422 @default.
- W2479450422 citedByCount "3" @default.
- W2479450422 crossrefType "book-chapter" @default.
- W2479450422 hasAuthorship W2479450422A5001501679 @default.
- W2479450422 hasAuthorship W2479450422A5039016384 @default.
- W2479450422 hasAuthorship W2479450422A5051750612 @default.
- W2479450422 hasAuthorship W2479450422A5075428131 @default.
- W2479450422 hasAuthorship W2479450422A5083384131 @default.
- W2479450422 hasConcept C104317684 @default.
- W2479450422 hasConcept C104428545 @default.
- W2479450422 hasConcept C107824862 @default.
- W2479450422 hasConcept C134306372 @default.
- W2479450422 hasConcept C147816474 @default.
- W2479450422 hasConcept C153911025 @default.
- W2479450422 hasConcept C159654299 @default.
- W2479450422 hasConcept C16318435 @default.
- W2479450422 hasConcept C167625842 @default.
- W2479450422 hasConcept C169627665 @default.
- W2479450422 hasConcept C178910836 @default.
- W2479450422 hasConcept C181199279 @default.
- W2479450422 hasConcept C185592680 @default.
- W2479450422 hasConcept C186268636 @default.
- W2479450422 hasConcept C197336794 @default.
- W2479450422 hasConcept C21951064 @default.
- W2479450422 hasConcept C2776471321 @default.
- W2479450422 hasConcept C2909223937 @default.
- W2479450422 hasConcept C29144244 @default.
- W2479450422 hasConcept C33923547 @default.
- W2479450422 hasConcept C40767141 @default.
- W2479450422 hasConcept C501734568 @default.
- W2479450422 hasConcept C542903549 @default.
- W2479450422 hasConcept C54355233 @default.
- W2479450422 hasConcept C55493867 @default.
- W2479450422 hasConcept C70721500 @default.
- W2479450422 hasConcept C85630698 @default.
- W2479450422 hasConcept C86803240 @default.
- W2479450422 hasConceptScore W2479450422C104317684 @default.
- W2479450422 hasConceptScore W2479450422C104428545 @default.
- W2479450422 hasConceptScore W2479450422C107824862 @default.
- W2479450422 hasConceptScore W2479450422C134306372 @default.
- W2479450422 hasConceptScore W2479450422C147816474 @default.
- W2479450422 hasConceptScore W2479450422C153911025 @default.
- W2479450422 hasConceptScore W2479450422C159654299 @default.
- W2479450422 hasConceptScore W2479450422C16318435 @default.
- W2479450422 hasConceptScore W2479450422C167625842 @default.
- W2479450422 hasConceptScore W2479450422C169627665 @default.
- W2479450422 hasConceptScore W2479450422C178910836 @default.
- W2479450422 hasConceptScore W2479450422C181199279 @default.
- W2479450422 hasConceptScore W2479450422C185592680 @default.
- W2479450422 hasConceptScore W2479450422C186268636 @default.
- W2479450422 hasConceptScore W2479450422C197336794 @default.
- W2479450422 hasConceptScore W2479450422C21951064 @default.
- W2479450422 hasConceptScore W2479450422C2776471321 @default.
- W2479450422 hasConceptScore W2479450422C2909223937 @default.
- W2479450422 hasConceptScore W2479450422C29144244 @default.
- W2479450422 hasConceptScore W2479450422C33923547 @default.
- W2479450422 hasConceptScore W2479450422C40767141 @default.
- W2479450422 hasConceptScore W2479450422C501734568 @default.
- W2479450422 hasConceptScore W2479450422C542903549 @default.
- W2479450422 hasConceptScore W2479450422C54355233 @default.
- W2479450422 hasConceptScore W2479450422C55493867 @default.
- W2479450422 hasConceptScore W2479450422C70721500 @default.
- W2479450422 hasConceptScore W2479450422C85630698 @default.
- W2479450422 hasConceptScore W2479450422C86803240 @default.
- W2479450422 hasLocation W24794504221 @default.
- W2479450422 hasOpenAccess W2479450422 @default.
- W2479450422 hasPrimaryLocation W24794504221 @default.
- W2479450422 hasRelatedWork W1964081304 @default.
- W2479450422 hasRelatedWork W1969502544 @default.
- W2479450422 hasRelatedWork W1988855265 @default.
- W2479450422 hasRelatedWork W2058703261 @default.
- W2479450422 hasRelatedWork W2060668400 @default.
- W2479450422 hasRelatedWork W2087432860 @default.
- W2479450422 hasRelatedWork W2382266631 @default.
- W2479450422 hasRelatedWork W2479450422 @default.
- W2479450422 hasRelatedWork W2522262866 @default.
- W2479450422 hasRelatedWork W4385484274 @default.
- W2479450422 isParatext "false" @default.
- W2479450422 isRetracted "false" @default.
- W2479450422 magId "2479450422" @default.
- W2479450422 workType "book-chapter" @default.