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- W2479554461 abstract "Procyanidins have been reported to modulate glucose homeostasis and ?-cell functionality. However, their effects on pancreatic cell mass remain unknown. Therefore, this doctoral thesis focused on the study of the effects of a grape seed procyanidin extract (GSPE) on proliferation and apoptosis processes in pancreatic cells. Our results indicate that although the extract did not affect these processes under healthy conditions, it modulated ?-cell proliferation and apoptosis under altered conditions. In vitro, GSPE enhanced the pro-apoptotic effects of high glucose and were antiproliferative under high glucose, insulin, and palmitate levels in the INS-1E cell line. In vivo, the effects of the extract depended on the dose, the duration of the treatment, and/or the gender. However, the extract tended to counteract the deleterious effects of the cafeteria diet or the Zucker Fatty genotype. Concerning the adenocarcinoma cell line MIA PaCa-2, GSPE exerted antiproliferative and pro-apoptotic effects, demonstrating anti-carcinogenic activity." @default.
- W2479554461 created "2016-08-23" @default.
- W2479554461 creator A5048128573 @default.
- W2479554461 date "2013-01-25" @default.
- W2479554461 modified "2023-09-26" @default.
- W2479554461 title "Effects of grape seed procyanidin extract on proliferation and apoptosis in pancreatic cells" @default.
- W2479554461 hasPublicationYear "2013" @default.
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