Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479685964> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2479685964 endingPage "1227" @default.
- W2479685964 startingPage "1227" @default.
- W2479685964 abstract "1227 Objectives PET myocardial perfusion imaging (MPI) holds several benefits for diagnosing coronary artery disease and related cardiac disorder. Previously, we have demonstrated the potential of the [18F]-trimethyl ammonium BODIPY dye for the cardiac imaging application. In this study, we report novel ammonium BODIPY derivatives and their capability as PET-MPI agents. Methods Three new cationic BODIPY dyes were prepared with different ammonium substituents, including ethyl, propyl, and benzyl groups (1, 2, and 3). The synthesized BODIPY dyes were radio-labeled via SnCl4-promoted 18F-19F isotopic exchange protocol. The resulting radiotracers were subjected to in vivo metabolic stability evaluation, microPET imaging, and biodistribution studies in murine model. Results The novel [18F]-ammonium BODIPY dyes were obtained in high radiochemical purity (>95%). Noninvasive microPET experiments revealed that the ethyl BODIPY showed the most promising heart uptake images. The biodistribution data demonstrated that the radioactivity uptake in the heart at 1 hour post-injection of the ethyl BODIPY (5.34 %ID/g) is higher than that of the propyl BODIPY (4.63 %ID/g) and the benzyl BODIPY (1.74 %ID/g), respectively, which are consistent with the microPET studies. Conclusions Our experiments displayed that subtle ammonium substituent changes have a drastic effect on the stability and the cardiac uptake of the [18F]-BODIPY dyes in murine model." @default.
- W2479685964 created "2016-08-23" @default.
- W2479685964 creator A5007896680 @default.
- W2479685964 creator A5036925342 @default.
- W2479685964 creator A5049067213 @default.
- W2479685964 creator A5070297217 @default.
- W2479685964 creator A5090366405 @default.
- W2479685964 date "2016-05-01" @default.
- W2479685964 modified "2023-09-24" @default.
- W2479685964 title "Evaluation of [18F]-ammonium BODIPY dyes as potential PET radiotracers for myocardial perfusion imaging" @default.
- W2479685964 hasPublicationYear "2016" @default.
- W2479685964 type Work @default.
- W2479685964 sameAs 2479685964 @default.
- W2479685964 citedByCount "0" @default.
- W2479685964 crossrefType "journal-article" @default.
- W2479685964 hasAuthorship W2479685964A5007896680 @default.
- W2479685964 hasAuthorship W2479685964A5036925342 @default.
- W2479685964 hasAuthorship W2479685964A5049067213 @default.
- W2479685964 hasAuthorship W2479685964A5070297217 @default.
- W2479685964 hasAuthorship W2479685964A5090366405 @default.
- W2479685964 hasConcept C121332964 @default.
- W2479685964 hasConcept C126322002 @default.
- W2479685964 hasConcept C146957229 @default.
- W2479685964 hasConcept C177322064 @default.
- W2479685964 hasConcept C178790620 @default.
- W2479685964 hasConcept C185592680 @default.
- W2479685964 hasConcept C202751555 @default.
- W2479685964 hasConcept C2777807558 @default.
- W2479685964 hasConcept C2778405248 @default.
- W2479685964 hasConcept C2779870022 @default.
- W2479685964 hasConcept C2781374752 @default.
- W2479685964 hasConcept C55493867 @default.
- W2479685964 hasConcept C62520636 @default.
- W2479685964 hasConcept C71924100 @default.
- W2479685964 hasConcept C91881484 @default.
- W2479685964 hasConceptScore W2479685964C121332964 @default.
- W2479685964 hasConceptScore W2479685964C126322002 @default.
- W2479685964 hasConceptScore W2479685964C146957229 @default.
- W2479685964 hasConceptScore W2479685964C177322064 @default.
- W2479685964 hasConceptScore W2479685964C178790620 @default.
- W2479685964 hasConceptScore W2479685964C185592680 @default.
- W2479685964 hasConceptScore W2479685964C202751555 @default.
- W2479685964 hasConceptScore W2479685964C2777807558 @default.
- W2479685964 hasConceptScore W2479685964C2778405248 @default.
- W2479685964 hasConceptScore W2479685964C2779870022 @default.
- W2479685964 hasConceptScore W2479685964C2781374752 @default.
- W2479685964 hasConceptScore W2479685964C55493867 @default.
- W2479685964 hasConceptScore W2479685964C62520636 @default.
- W2479685964 hasConceptScore W2479685964C71924100 @default.
- W2479685964 hasConceptScore W2479685964C91881484 @default.
- W2479685964 hasLocation W24796859641 @default.
- W2479685964 hasOpenAccess W2479685964 @default.
- W2479685964 hasPrimaryLocation W24796859641 @default.
- W2479685964 hasRelatedWork W1489900767 @default.
- W2479685964 hasRelatedWork W1934795257 @default.
- W2479685964 hasRelatedWork W2012268116 @default.
- W2479685964 hasRelatedWork W2033260859 @default.
- W2479685964 hasRelatedWork W2052511019 @default.
- W2479685964 hasRelatedWork W2057400573 @default.
- W2479685964 hasRelatedWork W2062693481 @default.
- W2479685964 hasRelatedWork W2122577534 @default.
- W2479685964 hasRelatedWork W2131955632 @default.
- W2479685964 hasRelatedWork W2173433747 @default.
- W2479685964 hasRelatedWork W2256675069 @default.
- W2479685964 hasRelatedWork W2279267781 @default.
- W2479685964 hasRelatedWork W2318660641 @default.
- W2479685964 hasRelatedWork W2331724384 @default.
- W2479685964 hasRelatedWork W2414842358 @default.
- W2479685964 hasRelatedWork W2591508734 @default.
- W2479685964 hasRelatedWork W2888844843 @default.
- W2479685964 hasRelatedWork W2891970189 @default.
- W2479685964 hasRelatedWork W2906002279 @default.
- W2479685964 hasRelatedWork W3202488889 @default.
- W2479685964 hasVolume "57" @default.
- W2479685964 isParatext "false" @default.
- W2479685964 isRetracted "false" @default.
- W2479685964 magId "2479685964" @default.
- W2479685964 workType "article" @default.