FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2479773088> ?p ?o ?g. }

• W2479773088 endingPage "129" @default.
• W2479773088 startingPage "123" @default.
• W2479773088 abstract "Human's ubiquitous exposure to di (2-ethylhexyl) phthalate (DEHP) is thought to be associated with female reproductive toxicity. Previous studies found that DEHP inhibited follicle growth and decreased estradiol levels in adult female mice. However, limited information is available on the link between in utero DEHP exposure and ovarian development in female mouse offspring. The present study evaluates the disturbances in regulatory genes involved in female sex determination and the ovarian outcomes in fetal and postnatal female mice treated with in utero DEHP exposure. Pregnant mice were exposed to DEHP by gavage, with the dosage regime beginning at human relevant exposure levels. After in utero DEHP exposure, increased follicular atresia was observed in the female pups at postnatal days (PND) 21. Foxl2 expression was significantly upregulated, and Fst was significantly downregulated by DEHP above 2 mg/kg/d at PND 1 and 21. This suggests that lesion of granulosa cell differentiation and disturbance of follicle development in postnatal female mice. The expression of Cyp11a1 and Star were significantly downregulated by in utero DEHP exposure, indicating effects on estradiol biosynthesis. The female sex determination pathway was disturbed in fetus by DEHP at 2 mg/kg/d and above during the critical time window of sex determination causing significant upregulation of Foxl2, Wnt4, β-catenin and Fst. Furthermore, the increased expression of Wnt4 was supported by whole-mount in situ hybridization (WISH). These results suggest a possible association between in utero DEHP exposure and precocious puberty in the postnatal life of mice offspring, where disturbance of the sex determination regulating pathway acted as an important mechanism." @default.
• W2479773088 created "2016-08-23" @default.
• W2479773088 creator A5008074653 @default.
• W2479773088 creator A5008854716 @default.
• W2479773088 creator A5010147521 @default.
• W2479773088 creator A5045241064 @default.
• W2479773088 creator A5064231427 @default.
• W2479773088 creator A5078268612 @default.
• W2479773088 date "2016-09-01" @default.
• W2479773088 modified "2023-10-15" @default.
• W2479773088 title "DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice" @default.
• W2479773088 cites W1111317693 @default.
• W2479773088 cites W1473089053 @default.
• W2479773088 cites W1749828410 @default.
• W2479773088 cites W1929944250 @default.
• W2479773088 cites W1963654383 @default.
• W2479773088 cites W1972208841 @default.
• W2479773088 cites W1974233507 @default.
• W2479773088 cites W1974708241 @default.
• W2479773088 cites W1977632514 @default.
• W2479773088 cites W1989517537 @default.
• W2479773088 cites W1998772634 @default.
• W2479773088 cites W1999005543 @default.
• W2479773088 cites W2010933273 @default.
• W2479773088 cites W2021780354 @default.
• W2479773088 cites W2023955385 @default.
• W2479773088 cites W2025886561 @default.
• W2479773088 cites W2034470409 @default.
• W2479773088 cites W2038649350 @default.
• W2479773088 cites W2041454621 @default.
• W2479773088 cites W2042041272 @default.
• W2479773088 cites W2066013811 @default.
• W2479773088 cites W2070969273 @default.
• W2479773088 cites W2078530840 @default.
• W2479773088 cites W2078711107 @default.
• W2479773088 cites W2080372347 @default.
• W2479773088 cites W2083460129 @default.
• W2479773088 cites W2084110570 @default.
• W2479773088 cites W2086181263 @default.
• W2479773088 cites W2088989921 @default.
• W2479773088 cites W2097633545 @default.
• W2479773088 cites W2109971484 @default.
• W2479773088 cites W2113042135 @default.
• W2479773088 cites W2114570899 @default.
• W2479773088 cites W2115176705 @default.
• W2479773088 cites W2120485749 @default.
• W2479773088 cites W2145863869 @default.
• W2479773088 cites W2166390226 @default.
• W2479773088 cites W2201971846 @default.
• W2479773088 cites W2324867729 @default.
• W2479773088 cites W2401340209 @default.
• W2479773088 cites W2412463294 @default.
• W2479773088 cites W4210977010 @default.
• W2479773088 cites W4237675840 @default.
• W2479773088 cites W4249970982 @default.
• W2479773088 doi "https://doi.org/10.1016/j.taap.2016.08.001" @default.
• W2479773088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27495896" @default.
• W2479773088 hasPublicationYear "2016" @default.
• W2479773088 type Work @default.
• W2479773088 sameAs 2479773088 @default.
• W2479773088 citedByCount "31" @default.
• W2479773088 countsByYear W24797730882017 @default.
• W2479773088 countsByYear W24797730882018 @default.
• W2479773088 countsByYear W24797730882019 @default.
• W2479773088 countsByYear W24797730882020 @default.
• W2479773088 countsByYear W24797730882021 @default.
• W2479773088 countsByYear W24797730882022 @default.
• W2479773088 countsByYear W24797730882023 @default.
• W2479773088 crossrefType "journal-article" @default.
• W2479773088 hasAuthorship W2479773088A5008074653 @default.
• W2479773088 hasAuthorship W2479773088A5008854716 @default.
• W2479773088 hasAuthorship W2479773088A5010147521 @default.
• W2479773088 hasAuthorship W2479773088A5045241064 @default.
• W2479773088 hasAuthorship W2479773088A5064231427 @default.
• W2479773088 hasAuthorship W2479773088A5078268612 @default.
• W2479773088 hasConcept C112672928 @default.
• W2479773088 hasConcept C126322002 @default.
• W2479773088 hasConcept C134018914 @default.
• W2479773088 hasConcept C172680121 @default.
• W2479773088 hasConcept C178790620 @default.
• W2479773088 hasConcept C185592680 @default.
• W2479773088 hasConcept C201614185 @default.
• W2479773088 hasConcept C2777668474 @default.
• W2479773088 hasConcept C2779234561 @default.
• W2479773088 hasConcept C2781005124 @default.
• W2479773088 hasConcept C54355233 @default.
• W2479773088 hasConcept C71924100 @default.
• W2479773088 hasConcept C86803240 @default.
• W2479773088 hasConceptScore W2479773088C112672928 @default.
• W2479773088 hasConceptScore W2479773088C126322002 @default.
• W2479773088 hasConceptScore W2479773088C134018914 @default.
• W2479773088 hasConceptScore W2479773088C172680121 @default.
• W2479773088 hasConceptScore W2479773088C178790620 @default.
• W2479773088 hasConceptScore W2479773088C185592680 @default.
• W2479773088 hasConceptScore W2479773088C201614185 @default.
• W2479773088 hasConceptScore W2479773088C2777668474 @default.
• W2479773088 hasConceptScore W2479773088C2779234561 @default.
• W2479773088 hasConceptScore W2479773088C2781005124 @default.

• next