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- W2479782210 endingPage "712" @default.
- W2479782210 startingPage "683" @default.
- W2479782210 abstract "In cardiac aging, there is increased molecular damage to nucleic acids, proteins, and lipids. This age-related accumulation of molecular damage is brought about by the inefficiency and failure of maintenance, repair and turnover pathways resulting in structural myocardial remodeling and dysfunction. Increasing focus in molecular gerontology has been directed at understanding the genetic and epigenetic regulation of myocardial survival and maintenance mechanisms at the levels of transcription, posttranscriptional processing, posttranslational modifications, and interactions among various gene products. Potential translational targets for modulating either aging or some of its more pathogenic cardiovascular manifestations will be discussed in this chapter. A number of these therapeutic targets have shown some evidence of success in early testing stages, and others wait for testing. Preclinical models including specific gene- and cell-based therapy and chemotherapeutic and metabolic modulation, including intervention by free radical scavengers and other molecules, will be also presented." @default.
- W2479782210 created "2016-08-23" @default.
- W2479782210 creator A5022739391 @default.
- W2479782210 date "2014-01-01" @default.
- W2479782210 modified "2023-09-26" @default.
- W2479782210 title "Targeted Strategies to Fight Cardiac Aging" @default.
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