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- W2480077467 abstract "DESCRIPTION Idebenone is a bioengineered analog, but not a derivative of ubiquinone (coenzyme Q10). It belongs in the family of molecules known as quinones, in particular it is a 1,4-benzoquinone molecule, as is hydroquinone. Its molecular weight is 338, compared with coenzyme Q10 with a molecular weight of 860, and therefore, in theory has much greater skin penetration potential. Idebenone is a potent antioxidant, with the ability to operate under low oxygen tension situations, and not showing prooxidative metabolites (1,2). Because of its ability to inhibit lipid peroxidation, idebenone protects cell membranes and mitochondria from oxidative damage caused by free radicals generated during cell metabolism, processes which are also summarized as intrinsic aging (2–4). Ultraviolet radiation (UVR)-generated reactive oxygen species (ROS) play a critical role in the process of photocarcinogenesis and environmentally induced aging, also termed as photoaging or extrinsic aging (5–9). Recent studies claim that also infrared radiation and visible light contribute to a major extend to such kind of damage (10,11). Although the skin possesses a complex antioxidant network, both intrinsic and extrinsic pathways can provoke an imbalance of the fragile prooxidant-antioxidant equilibrium (12–17) eventually leading to alteration of cells and structural macromolecules of the dermal connective tissue with its clinical appearance of wrinkle formation, laxity and pigment disorders. In comparison with other antioxidants, idebenone shows in vitro studies as well as in vivo studies unique properties providing protection regarding both intrinsic and extrinsic processes of aging (18–20)." @default.
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- W2480077467 date "2010-10-01" @default.
- W2480077467 modified "2023-09-26" @default.
- W2480077467 title "Idebenone (hydroxydecyl ubiquinone)" @default.
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- W2480077467 doi "https://doi.org/10.3109/9781841847641.012" @default.
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