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• W2480096122 abstract "Publisher Summary Epidemiology is the study of the distribution of illnesses and diseases and the factors affecting their incidence and clinical course in the population. Systemic lupus erythematosus (SLE), an autoimmune disease with a broad spectrum of clinical and immunological manifestations, is a major challenge to study epidemiologically, but research on SLE has been carried out in many parts of the world. These include descriptive studies of incidence and prevalence, observational studies of SLE prognosis, and the identification of potentially preventable causes of morbidity and mortality. Analytic and genetic epidemiologic studies suggest a multifactorial etiology of SLE. A better understanding of the epidemiology of SLE should help us understand its etiology, identify predictors of morbidity and mortality, and improve SLE care and outcomes. Epidemiologic clues for potential cause(s) remain elusive, not so much from lack of effort, but lack of strong signals. Even the most established risk factors, except for gender, explain the minority of cases. Overall, epidemiologic studies demonstrate a good and possibly improved prognosis since its first description, making SLE a chronic but potentially dangerous illness. Studies also indicate considerable variations in outcome and differences between ethnic groups and between industrial and preindustrial countries that are probably increasing, comprising a major research challenge and a possible public health opportunity to correct these inequalities. Long-term morbidity is appreciated but its study is only just beginning. Future studies will need to look at what is really modifiable and to test interventions rigorously." @default.
• W2480096122 created "2016-08-23" @default.
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• W2480096122 date "2011-01-01" @default.
• W2480096122 modified "2023-09-30" @default.
• W2480096122 title "Epidemiology of Systemic Lupus Erythematosus" @default.
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