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• W2480096715 endingPage "613" @default.
• W2480096715 startingPage "605" @default.
• W2480096715 abstract "The journey of secretory vesicles to the plasma membrane is prompted by stimulation, involves different transport zones, and is sensitive to actin-depolymerizing drugs. In the central zone most vesicles undergo free motion, in the subcortical zone vesicles are actively transported, and in the cortical zone vesicles are highly confined. Actomyosin II provides changes in tensional forces promoting vesicle docking and, in concert with SNARE proteins co-localized with calcium channels at the borders of F-actin cages, accelerates the release of catecholamines during fusion pore opening. Compensatory bulk endocytosis requires an actomyosin II contractile ring. Constriction of actomyosin II rings transiently surrounding the bulk endosomes is key to promoting vesicle fission. Phosphatidylinositol 4,5-bisphosphate, dynamin, and myosin II contribute to initiating this bulk invagination. The cortical actin network is a tight array of filaments located beneath the plasma membrane. In neurosecretory cells, secretory vesicles are recruited on this network via a small insert isoform of myosin VI in a Ca2+-dependent manner. Upon secretagogue stimulation, myosin II mediates a relaxation of the actin network leading to synchronous translocation of bound or caged vesicles to the plasma membrane where they undergo exocytosis. F-actin is also recruited to secretory sites, where structural changes are detected immediately preceding and following exocytic events. Here we examine the mechanism underpinning the astonishing multifunctionality of this network in the various stages of vesicular exocytosis and compensatory bulk endocytosis. We propose a theoretical framework incorporating critical roles of the actin network in coupling these processes. The cortical actin network is a tight array of filaments located beneath the plasma membrane. In neurosecretory cells, secretory vesicles are recruited on this network via a small insert isoform of myosin VI in a Ca2+-dependent manner. Upon secretagogue stimulation, myosin II mediates a relaxation of the actin network leading to synchronous translocation of bound or caged vesicles to the plasma membrane where they undergo exocytosis. F-actin is also recruited to secretory sites, where structural changes are detected immediately preceding and following exocytic events. Here we examine the mechanism underpinning the astonishing multifunctionality of this network in the various stages of vesicular exocytosis and compensatory bulk endocytosis. We propose a theoretical framework incorporating critical roles of the actin network in coupling these processes. an electrophysiological technique used to measure the release of neurotransmitters from secretory vesicles by detecting the current produced by the oxidation of catecholamines at the tip of a carbon fiber microelectrode placed a short distance of the plasma membrane. transient opening between a secretory vesicle and the plasma membrane that allows the partial release of vesicular content into the extracellular space. different modes of exocytosis with incomplete release of neurotransmitters following transient opening of the fusion pore (“kiss and run”) or full incorporation of the vesicle membrane with the plasma membrane thereby allowing complete release of its neurotransmitter content (full fusion). two major routes of the endocytic pathway that either recycles internalized cargos back to the Golgi apparatus or to lysosomes for degradation. chemical compound used to promote the release of neurotransmitters or hormones by exocytosis. secretory vesicles, also known as large dense-core vesicles, are relatively large (80–300 nm diameter) and exhibit a dense core containing neuropeptides and catecholamine as found in neuroendocrine cells. Synaptic vesicles are smaller (30–50 nm diameter), contain classical neurotransmitters, and are found mostly in nerve terminals. TIRF (total internal reflection fluorescence) microscopy is a technique used to selectively excite fluorophores in the evanescence wave, a narrow (100–300 nm) field of illumination generated by a laser beam reaching the critical angle of reflection at the glass-water interface." @default.
• W2480096715 created "2016-08-23" @default.
• W2480096715 creator A5019459840 @default.
• W2480096715 creator A5051533242 @default.
• W2480096715 date "2016-09-01" @default.
• W2480096715 modified "2023-10-14" @default.
• W2480096715 title "Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells" @default.
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