Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480173037> ?p ?o ?g. }
- W2480173037 abstract "Chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS), resulting in only an approximately 20 % survival rate in patients with metastatic disease at diagnosis. Identifying the mechanisms responsible for regulating chemotherapy resistance is crucial for improving OS treatment. This study was performed in two human OS cell lines (the multi-chemosensitive OS cell line G-292 and the multi-chemoresistant OS cell line SJSA-1). The levels of miR-20a-5p and KIF26B mRNA expression were determined by quantitative real-time PCR. KIF26B protein levels were determined by western blot analysis. Cell viability was assessed by MTT assay. Apoptosis was evaluated by flow cytometry. We found that miR-20a-5p was more highly expressed in G-292 cells than in SJSA-1 cells. Forced expression of miR-20a-5p counteracted OS cell chemoresistance in both cell culture and tumor xenografts in nude mice. One of miR-20a-5p’s targets, kinesin family member 26B (KIF26B), was found to mediate the miR-20a-5p-induced reduction in OS chemoresistance by modulating the activities of the MAPK/ERK and cAMP/PKA signaling pathways. In addition to providing mechanistic insights, our study revealed that miR-20a-5p and KIF26B contribute to OS chemoresistance and determined the roles of these genes in this process, which may be critical for characterizing drug responsiveness and overcoming chemoresistance in OS patients." @default.
- W2480173037 created "2016-08-23" @default.
- W2480173037 creator A5013014400 @default.
- W2480173037 creator A5022728200 @default.
- W2480173037 creator A5044089259 @default.
- W2480173037 creator A5046268298 @default.
- W2480173037 creator A5047700587 @default.
- W2480173037 creator A5088927271 @default.
- W2480173037 date "2016-08-05" @default.
- W2480173037 modified "2023-10-17" @default.
- W2480173037 title "MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene" @default.
- W2480173037 cites W144423133 @default.
- W2480173037 cites W1505960326 @default.
- W2480173037 cites W1577767290 @default.
- W2480173037 cites W1578530056 @default.
- W2480173037 cites W1595361570 @default.
- W2480173037 cites W1604468403 @default.
- W2480173037 cites W177500088 @default.
- W2480173037 cites W1964485249 @default.
- W2480173037 cites W1966680971 @default.
- W2480173037 cites W1968076374 @default.
- W2480173037 cites W1975716064 @default.
- W2480173037 cites W1988325237 @default.
- W2480173037 cites W1992814850 @default.
- W2480173037 cites W1994127846 @default.
- W2480173037 cites W1998712202 @default.
- W2480173037 cites W1999998565 @default.
- W2480173037 cites W2007618944 @default.
- W2480173037 cites W2008221551 @default.
- W2480173037 cites W2011938376 @default.
- W2480173037 cites W2013060968 @default.
- W2480173037 cites W2015041641 @default.
- W2480173037 cites W2018702739 @default.
- W2480173037 cites W2022162825 @default.
- W2480173037 cites W2024072564 @default.
- W2480173037 cites W2024342817 @default.
- W2480173037 cites W2026758079 @default.
- W2480173037 cites W2026956609 @default.
- W2480173037 cites W2035477757 @default.
- W2480173037 cites W2037207845 @default.
- W2480173037 cites W2041485960 @default.
- W2480173037 cites W2042392104 @default.
- W2480173037 cites W2052957185 @default.
- W2480173037 cites W2055904567 @default.
- W2480173037 cites W2055931677 @default.
- W2480173037 cites W2056351312 @default.
- W2480173037 cites W2058246513 @default.
- W2480173037 cites W2060014806 @default.
- W2480173037 cites W2062325757 @default.
- W2480173037 cites W2068379194 @default.
- W2480173037 cites W2073006837 @default.
- W2480173037 cites W2073098012 @default.
- W2480173037 cites W2074238963 @default.
- W2480173037 cites W2081940894 @default.
- W2480173037 cites W2083381199 @default.
- W2480173037 cites W2084429794 @default.
- W2480173037 cites W2086025878 @default.
- W2480173037 cites W2087625283 @default.
- W2480173037 cites W2088695750 @default.
- W2480173037 cites W2092645267 @default.
- W2480173037 cites W2099008186 @default.
- W2480173037 cites W2099225277 @default.
- W2480173037 cites W2100137129 @default.
- W2480173037 cites W2100181965 @default.
- W2480173037 cites W2112251383 @default.
- W2480173037 cites W2114413726 @default.
- W2480173037 cites W2123959488 @default.
- W2480173037 cites W2125233650 @default.
- W2480173037 cites W2130819396 @default.
- W2480173037 cites W2153906296 @default.
- W2480173037 cites W2159343208 @default.
- W2480173037 cites W2161106528 @default.
- W2480173037 cites W2162465955 @default.
- W2480173037 cites W2162946128 @default.
- W2480173037 cites W2162961035 @default.
- W2480173037 cites W2164680495 @default.
- W2480173037 cites W2167548363 @default.
- W2480173037 cites W2168276925 @default.
- W2480173037 cites W2170506841 @default.
- W2480173037 cites W2171508711 @default.
- W2480173037 cites W2171973865 @default.
- W2480173037 cites W2331994105 @default.
- W2480173037 cites W2332022882 @default.
- W2480173037 cites W90430858 @default.
- W2480173037 doi "https://doi.org/10.1186/s12935-016-0340-3" @default.
- W2480173037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4974744" @default.
- W2480173037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499703" @default.
- W2480173037 hasPublicationYear "2016" @default.
- W2480173037 type Work @default.
- W2480173037 sameAs 2480173037 @default.
- W2480173037 citedByCount "38" @default.
- W2480173037 countsByYear W24801730372017 @default.
- W2480173037 countsByYear W24801730372018 @default.
- W2480173037 countsByYear W24801730372019 @default.
- W2480173037 countsByYear W24801730372020 @default.
- W2480173037 countsByYear W24801730372021 @default.
- W2480173037 countsByYear W24801730372022 @default.
- W2480173037 countsByYear W24801730372023 @default.
- W2480173037 crossrefType "journal-article" @default.
- W2480173037 hasAuthorship W2480173037A5013014400 @default.