Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480190410> ?p ?o ?g. }
- W2480190410 abstract "Abstract O 6 -Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the cytotoxic DNA adducts O 6 -methylguanine and O 6 -chloroethylguanine induced by methylating (procarbazine, dacarbazine, streptozotocine, temozolomide) and chloroethylating (lomustine, nimustine, carmustine, fotemustine) anticancer drugs, respectively. MGMT represents an important factor in the resistance of tumors treated with these alkylating agents. Since O 6 -alkylguanine is not only a toxic DNA lesion but also one that initiates tumorigenesis, MGMT is at the same time a key node in the defense against cancer formation. Here we describe how MGMT protects against the activation of cell death pathways triggered by O 6 -alkylguanine, the methods employed for detecting MGMT and summarize data concerning the regulation of MGMT, its expression in normal and malignant cells, and its validation as a predictive/prognostic factor in cancer therapy. Furthermore, we discuss strategies for targeting MGMT using MGMT inhibitors in order to improve the efficiency of alkylating agent-based therapy." @default.
- W2480190410 created "2016-08-23" @default.
- W2480190410 creator A5003911654 @default.
- W2480190410 creator A5026593378 @default.
- W2480190410 date "2016-01-01" @default.
- W2480190410 modified "2023-10-16" @default.
- W2480190410 title "MGMT—a critical DNA repair gene target for chemotherapy resistance" @default.
- W2480190410 cites W111616551 @default.
- W2480190410 cites W1479720950 @default.
- W2480190410 cites W1520098239 @default.
- W2480190410 cites W1537479709 @default.
- W2480190410 cites W1538045376 @default.
- W2480190410 cites W1543756548 @default.
- W2480190410 cites W1550044269 @default.
- W2480190410 cites W1552690727 @default.
- W2480190410 cites W1582226512 @default.
- W2480190410 cites W1588444780 @default.
- W2480190410 cites W159383995 @default.
- W2480190410 cites W1598305631 @default.
- W2480190410 cites W1607924860 @default.
- W2480190410 cites W1651982135 @default.
- W2480190410 cites W1658127082 @default.
- W2480190410 cites W1783782681 @default.
- W2480190410 cites W1828007370 @default.
- W2480190410 cites W1869160040 @default.
- W2480190410 cites W1886120862 @default.
- W2480190410 cites W1904349774 @default.
- W2480190410 cites W1911801098 @default.
- W2480190410 cites W1916931627 @default.
- W2480190410 cites W1917632054 @default.
- W2480190410 cites W1922368942 @default.
- W2480190410 cites W1929295557 @default.
- W2480190410 cites W1939406351 @default.
- W2480190410 cites W1963581476 @default.
- W2480190410 cites W1964123122 @default.
- W2480190410 cites W1964422747 @default.
- W2480190410 cites W1965583321 @default.
- W2480190410 cites W1965699576 @default.
- W2480190410 cites W1966091763 @default.
- W2480190410 cites W1966988700 @default.
- W2480190410 cites W1969885428 @default.
- W2480190410 cites W1970963988 @default.
- W2480190410 cites W1972827668 @default.
- W2480190410 cites W1975104842 @default.
- W2480190410 cites W1976840830 @default.
- W2480190410 cites W1977838174 @default.
- W2480190410 cites W1978116682 @default.
- W2480190410 cites W1978146094 @default.
- W2480190410 cites W1978853965 @default.
- W2480190410 cites W1978975870 @default.
- W2480190410 cites W1980494115 @default.
- W2480190410 cites W1981078074 @default.
- W2480190410 cites W1982993379 @default.
- W2480190410 cites W1984078809 @default.
- W2480190410 cites W1986500247 @default.
- W2480190410 cites W1986972223 @default.
- W2480190410 cites W1987073169 @default.
- W2480190410 cites W1987152771 @default.
- W2480190410 cites W1987580232 @default.
- W2480190410 cites W1988255080 @default.
- W2480190410 cites W1988299559 @default.
- W2480190410 cites W1989138344 @default.
- W2480190410 cites W1989451396 @default.
- W2480190410 cites W1989874893 @default.
- W2480190410 cites W1989969436 @default.
- W2480190410 cites W1991000956 @default.
- W2480190410 cites W1994465394 @default.
- W2480190410 cites W1994629807 @default.
- W2480190410 cites W1996071718 @default.
- W2480190410 cites W1996872556 @default.
- W2480190410 cites W1997115158 @default.
- W2480190410 cites W2004836271 @default.
- W2480190410 cites W2006524674 @default.
- W2480190410 cites W2007247567 @default.
- W2480190410 cites W2007704672 @default.
- W2480190410 cites W2009143954 @default.
- W2480190410 cites W2010511761 @default.
- W2480190410 cites W2011203407 @default.
- W2480190410 cites W2013682516 @default.
- W2480190410 cites W2015651919 @default.
- W2480190410 cites W2017442627 @default.
- W2480190410 cites W2018938581 @default.
- W2480190410 cites W2019558377 @default.
- W2480190410 cites W2020308175 @default.
- W2480190410 cites W2021210732 @default.
- W2480190410 cites W2022799922 @default.
- W2480190410 cites W2024205486 @default.
- W2480190410 cites W2024930656 @default.
- W2480190410 cites W2026538210 @default.
- W2480190410 cites W2027141079 @default.
- W2480190410 cites W2031371983 @default.
- W2480190410 cites W2035021866 @default.
- W2480190410 cites W2041657197 @default.
- W2480190410 cites W2044415369 @default.
- W2480190410 cites W2046098727 @default.
- W2480190410 cites W2046371943 @default.
- W2480190410 cites W2046833996 @default.
- W2480190410 cites W2046938856 @default.
- W2480190410 cites W2047710431 @default.
- W2480190410 cites W2048873043 @default.