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• W2480202340 abstract "Copper (II) oxide nanoparticles (CuO-NPs) have been used in industry, cosmetics, and medicine. Gradually increased human exposure to CuO-NPs can cause undesirable effects in humans and the ecosystem. Although a few studies indicate that CuO-NPs can damage organs/systems, we still lack data on the toxicological effects of CuO-NPs in kidneys. In the present study, the nephrotoxic potential of CuO-NPs was investigated in in vitro conditions. The following assays were used: transmission electron microscopy and inductively coupled plasma mass spectrometry for particle characterization and determination of cellular uptake; MTT and neutral red uptake assays for cytotoxicity; comet assay for genotoxicity; enzyme-linked immune sorbent assay (ELISA) determination of malondialdehyde (MDA), 8-hydroxy-deoxyguanosine (8-OHdG), protein carbonyl (PC), and glutathione (GSH) levels for oxidative damage; and Annexin V-FITC apoptosis detection assay with propidium iodide (PI) for apoptosis. Our results show that CuO-NPs (34.9 nm) caused significant cytotoxicity (IC50: 11.6–16.4 μg/mL), genotoxicity (1.9- to 8.4-fold), and oxidative and apoptotic effects in the range of 2.5–80 μg/mL in kidney cells. In conclusion, CuO-NPs are hypothesized to negatively affect human health and caused nephrotoxicity. However, further studies should be better to elucidate their toxic mechanism." @default.
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• W2480202340 date "2016-09-01" @default.
• W2480202340 modified "2023-09-24" @default.
• W2480202340 title "Copper (II) Oxide Nanoparticles Induced Nephrotoxicity <i>In Vitro</i> Conditions" @default.
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• W2480202340 doi "https://doi.org/10.1089/aivt.2016.0008" @default.
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