Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480208901> ?p ?o ?g. }
- W2480208901 abstract "Publisher Summary The actions of opiates upon nervous tissue are mediated by specific receptors that bind opiates with high affinity and discriminate between the biologically active (−) isomers and the relatively inactive (+) isomers. This chapter describes current issues and methodologies of opiate receptors. Opiate receptors appear to be negatively coupled to adenylate cyclase in neuroblastoma × glioma cells and in monkey amygdala. The question arises whether guanyl nucleotides regulate opiate binding by a direct allosteric interaction or indirectly through an interaction with a cyclase-GTP binding protein complex or both. The phenomena of tolerance and dependence raise the question as to whether brain opiate receptors undergo up or down regulation. There are three general cases that have been observed for opiate receptor-ligand interactions. First, a homogenous, noninteracting population of receptor sites may bind ligand according to the law of mass action. Second, there may be multiple, noninteracting receptor subtypes present that bind the ligand with differing affinities. Third, there may be a single population of receptor sites that binds the ligand in a cooperative manner." @default.
- W2480208901 created "2016-08-23" @default.
- W2480208901 creator A5052806674 @default.
- W2480208901 date "1984-01-01" @default.
- W2480208901 modified "2023-09-26" @default.
- W2480208901 title "OPIATE RECEPTORS: CURRENT ISSUES AND METHODOLOGIES" @default.
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