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- W2480268634 abstract "ABSTRACT. Neoplastic B lymphocytes from patients with chronic lymphocytic leukemia or follicular lymphoma often export immunoglobulin and measurement of such idiotypic immunoglobulin in serum can be used to indicate disease load. An idiotype assay has been used to monitor the response of a patient to separate courses of chemotherapy, and immunotherapy with anti-idiotype. Chemotherapy caused a fall in circulating lymphocytes and a transient rise in serum idiotype due to release of IgM. For immunotherapy, serum idiotype was reduced initially by plasmapheresis and then further by anti-idiotype at the same time as other parameters showed loss of tumor cells." @default.
- W2480268634 created "2016-08-23" @default.
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- W2480268634 date "1982-01-01" @default.
- W2480268634 modified "2023-09-26" @default.
- W2480268634 title "IDIOTYPIC IMMUNOGLOBULIN PRODUCTION BY HUMAN NEOPLASTIC B LYMPHOCYTES: ITS USE IN MONITORING CHEMOTHERAPY AND IMMUNOTHERAPY11This work was supported by grants from Tenovus of Cardiff, the Medical Research Council and the Cancer Research Campaign, U.K." @default.
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- W2480268634 doi "https://doi.org/10.1016/b978-0-12-722380-3.50067-2" @default.
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