FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480303467> ?p ?o ?g. }

• W2480303467 abstract "Background Huntington's disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral frontostriatal circuits, and structural integrity of the striatum itself. We aimed to investigate whether size and shape of the striatum as a measure of frontostriatal circuit structural integrity was correlated with functional frontostriatal electrophysiological neural premotor processing (contingent negative variation, CNV), to better understand motoric structure–function relationships in early HD. Methods Magnetic resonance imaging (MRI) scans and electrophysiological (EEG) measures of premotor processing were obtained from a combined HD group (12 presymptomatic, 7 symptomatic). Manual segmentation of caudate and putamen was conducted with subsequent shape analysis. Separate correlational analyses (volume and shape) included covariates of age, gender, intracranial volume, and time between EEG and MRI. Results Right caudate volume correlated with early CNV latency over frontocentral regions and late CNV frontally, whereas right caudate shape correlated with early CNV latency centrally. Left caudate volume correlated with early CNV latency over centroparietal regions and late CNV frontally. Right and left putamen volumes correlated with early CNV latency frontally, and right and left putamen shape/volume correlated with parietal CNV slope. Conclusions Timing (latency) and pattern (slope) of frontostriatal circuit-mediated premotor functional activation across scalp regions were correlated with abnormalities in structural integrity of the key frontostriatal circuit component, the striatum (size and shape). This was accompanied by normal reaction times, suggesting it may be undetected in regular tasks due to preserved motor “performance.” Such differences in functional activation may reflect atrophy-based frontostriatal circuitry despecialization and/or compensatory recruitment of additional brain regions." @default.
• W2480303467 created "2016-08-23" @default.
• W2480303467 creator A5005081020 @default.
• W2480303467 creator A5006657375 @default.
• W2480303467 creator A5026788805 @default.
• W2480303467 creator A5027917089 @default.
• W2480303467 creator A5039280794 @default.
• W2480303467 creator A5059823463 @default.
• W2480303467 creator A5062836667 @default.
• W2480303467 creator A5077268112 @default.
• W2480303467 creator A5081853833 @default.
• W2480303467 creator A5086213684 @default.
• W2480303467 date "2016-07-27" @default.
• W2480303467 modified "2023-10-01" @default.
• W2480303467 title "Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE‐HD study" @default.
• W2480303467 cites W1598342602 @default.
• W2480303467 cites W1938119680 @default.
• W2480303467 cites W1965124253 @default.
• W2480303467 cites W1966094061 @default.
• W2480303467 cites W1968499012 @default.
• W2480303467 cites W1971776426 @default.
• W2480303467 cites W1978178248 @default.
• W2480303467 cites W1979567311 @default.
• W2480303467 cites W1980255458 @default.
• W2480303467 cites W1985367358 @default.
• W2480303467 cites W1986063140 @default.
• W2480303467 cites W1990248618 @default.
• W2480303467 cites W1992173091 @default.
• W2480303467 cites W1996990492 @default.
• W2480303467 cites W2000430436 @default.
• W2480303467 cites W2005429175 @default.
• W2480303467 cites W2010846710 @default.
• W2480303467 cites W2024954481 @default.
• W2480303467 cites W2027946127 @default.
• W2480303467 cites W2028942474 @default.
• W2480303467 cites W2034987376 @default.
• W2480303467 cites W2036150705 @default.
• W2480303467 cites W2038012828 @default.
• W2480303467 cites W2045518898 @default.
• W2480303467 cites W2048599819 @default.
• W2480303467 cites W2054314089 @default.
• W2480303467 cites W2057916780 @default.
• W2480303467 cites W2061162179 @default.
• W2480303467 cites W2069430900 @default.
• W2480303467 cites W2076615772 @default.
• W2480303467 cites W2082047046 @default.
• W2480303467 cites W2082056883 @default.
• W2480303467 cites W2082103528 @default.
• W2480303467 cites W2084021017 @default.
• W2480303467 cites W2086738241 @default.
• W2480303467 cites W2095034527 @default.
• W2480303467 cites W2099652807 @default.
• W2480303467 cites W2113661629 @default.
• W2480303467 cites W2124660038 @default.
• W2480303467 cites W2125285219 @default.
• W2480303467 cites W2127775493 @default.
• W2480303467 cites W2129250133 @default.
• W2480303467 cites W2129675116 @default.
• W2480303467 cites W2132520630 @default.
• W2480303467 cites W2134877699 @default.
• W2480303467 cites W2145997442 @default.
• W2480303467 cites W2148660689 @default.
• W2480303467 cites W2149807210 @default.
• W2480303467 cites W2150857753 @default.
• W2480303467 cites W2159601677 @default.
• W2480303467 cites W2160437678 @default.
• W2480303467 cites W2163671213 @default.
• W2480303467 cites W2169735361 @default.
• W2480303467 cites W2172252744 @default.
• W2480303467 cites W2333870512 @default.
• W2480303467 cites W2340545484 @default.
• W2480303467 cites W4297067014 @default.
• W2480303467 doi "https://doi.org/10.1002/brb3.511" @default.
• W2480303467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5167007" @default.
• W2480303467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28031992" @default.
• W2480303467 hasPublicationYear "2016" @default.
• W2480303467 type Work @default.
• W2480303467 sameAs 2480303467 @default.
• W2480303467 citedByCount "6" @default.
• W2480303467 countsByYear W24803034672017 @default.
• W2480303467 countsByYear W24803034672019 @default.
• W2480303467 countsByYear W24803034672020 @default.
• W2480303467 countsByYear W24803034672023 @default.
• W2480303467 crossrefType "journal-article" @default.
• W2480303467 hasAuthorship W2480303467A5005081020 @default.
• W2480303467 hasAuthorship W2480303467A5006657375 @default.
• W2480303467 hasAuthorship W2480303467A5026788805 @default.
• W2480303467 hasAuthorship W2480303467A5027917089 @default.
• W2480303467 hasAuthorship W2480303467A5039280794 @default.
• W2480303467 hasAuthorship W2480303467A5059823463 @default.
• W2480303467 hasAuthorship W2480303467A5062836667 @default.
• W2480303467 hasAuthorship W2480303467A5077268112 @default.
• W2480303467 hasAuthorship W2480303467A5081853833 @default.
• W2480303467 hasAuthorship W2480303467A5086213684 @default.
• W2480303467 hasBestOaLocation W24803034671 @default.
• W2480303467 hasConcept C15744967 @default.
• W2480303467 hasConcept C169760540 @default.
• W2480303467 hasConcept C185263204 @default.
• W2480303467 hasConcept C2779714222 @default.
• W2480303467 hasConcept C2780062018 @default.

• next