Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480340708> ?p ?o ?g. }
- W2480340708 endingPage "624" @default.
- W2480340708 startingPage "619" @default.
- W2480340708 abstract "Recently, thioredoxin reductase as a target for treatment of tumors has attracted the attention of scientists. 1,2‐[Bis(1,2‐benzisoselenazolone‐3(2 H )‐ketone)]ethane (ethaselen, BBSKE, PCT: CN02/00412), designed and synthesized previously, is an effective thioredoxin reductase inhibitor; presently it is in phase II clinical trials, targeting gastric cancer, lung cancer and colon cancer. To seek more novel and effective anticancer drugs, we have developed many selenazole‐based compounds. Evaluation of the thioredoxin reductase inhibitory effect and investigation of the mechanism of anticancer drugs require abundant thioredoxin reductase, but since commercial thioredoxin reductase is expensive its use is often limited. Therefore, the preparation of thioredoxin reductase is necessary. Base on the above investigation, in this work we have prepared thioredoxin reductase and evaluated selenazole‐based compounds, and found that 44 compounds have high inhibitory effect on thioredoxin reductase with IC 50 < 10 µ m , of which 16 compounds have IC 50 values below 1 µ m . This is helpful in investigating and elucidating the mechanism of this kind of compound. Copyright © 2012 John Wiley & Sons, Ltd." @default.
- W2480340708 created "2016-08-23" @default.
- W2480340708 creator A5016407273 @default.
- W2480340708 creator A5025013056 @default.
- W2480340708 creator A5069923589 @default.
- W2480340708 date "2012-09-24" @default.
- W2480340708 modified "2023-10-18" @default.
- W2480340708 title "Biological evaluation of novel selenazole-based compounds as potential thioredoxin reductase inhibitors" @default.
- W2480340708 cites W1513390880 @default.
- W2480340708 cites W1583295309 @default.
- W2480340708 cites W1830800654 @default.
- W2480340708 cites W1976161942 @default.
- W2480340708 cites W1978173290 @default.
- W2480340708 cites W1980335366 @default.
- W2480340708 cites W1983147023 @default.
- W2480340708 cites W1987744079 @default.
- W2480340708 cites W1991303607 @default.
- W2480340708 cites W1992533564 @default.
- W2480340708 cites W2007077269 @default.
- W2480340708 cites W2008820074 @default.
- W2480340708 cites W2020297152 @default.
- W2480340708 cites W2021816119 @default.
- W2480340708 cites W2025470807 @default.
- W2480340708 cites W2031787079 @default.
- W2480340708 cites W2039759271 @default.
- W2480340708 cites W2044950028 @default.
- W2480340708 cites W2045787232 @default.
- W2480340708 cites W2048035379 @default.
- W2480340708 cites W2055849442 @default.
- W2480340708 cites W2056605364 @default.
- W2480340708 cites W2063828804 @default.
- W2480340708 cites W2070291783 @default.
- W2480340708 cites W2075429854 @default.
- W2480340708 cites W2076159984 @default.
- W2480340708 cites W2080913348 @default.
- W2480340708 cites W2082108728 @default.
- W2480340708 cites W2086793077 @default.
- W2480340708 cites W2088229678 @default.
- W2480340708 cites W2089999198 @default.
- W2480340708 cites W2091772550 @default.
- W2480340708 cites W2114098967 @default.
- W2480340708 cites W2139269338 @default.
- W2480340708 cites W2158788819 @default.
- W2480340708 cites W2171258641 @default.
- W2480340708 doi "https://doi.org/10.1002/aoc.2910" @default.
- W2480340708 hasPublicationYear "2012" @default.
- W2480340708 type Work @default.
- W2480340708 sameAs 2480340708 @default.
- W2480340708 citedByCount "7" @default.
- W2480340708 countsByYear W24803407082012 @default.
- W2480340708 countsByYear W24803407082014 @default.
- W2480340708 countsByYear W24803407082015 @default.
- W2480340708 countsByYear W24803407082021 @default.
- W2480340708 countsByYear W24803407082022 @default.
- W2480340708 crossrefType "journal-article" @default.
- W2480340708 hasAuthorship W2480340708A5016407273 @default.
- W2480340708 hasAuthorship W2480340708A5025013056 @default.
- W2480340708 hasAuthorship W2480340708A5069923589 @default.
- W2480340708 hasConcept C104292427 @default.
- W2480340708 hasConcept C104317684 @default.
- W2480340708 hasConcept C134651460 @default.
- W2480340708 hasConcept C181199279 @default.
- W2480340708 hasConcept C185592680 @default.
- W2480340708 hasConcept C2777737464 @default.
- W2480340708 hasConcept C3623737 @default.
- W2480340708 hasConcept C4710235 @default.
- W2480340708 hasConcept C55493867 @default.
- W2480340708 hasConcept C70412867 @default.
- W2480340708 hasConcept C86803240 @default.
- W2480340708 hasConcept C98274493 @default.
- W2480340708 hasConceptScore W2480340708C104292427 @default.
- W2480340708 hasConceptScore W2480340708C104317684 @default.
- W2480340708 hasConceptScore W2480340708C134651460 @default.
- W2480340708 hasConceptScore W2480340708C181199279 @default.
- W2480340708 hasConceptScore W2480340708C185592680 @default.
- W2480340708 hasConceptScore W2480340708C2777737464 @default.
- W2480340708 hasConceptScore W2480340708C3623737 @default.
- W2480340708 hasConceptScore W2480340708C4710235 @default.
- W2480340708 hasConceptScore W2480340708C55493867 @default.
- W2480340708 hasConceptScore W2480340708C70412867 @default.
- W2480340708 hasConceptScore W2480340708C86803240 @default.
- W2480340708 hasConceptScore W2480340708C98274493 @default.
- W2480340708 hasIssue "11" @default.
- W2480340708 hasLocation W24803407081 @default.
- W2480340708 hasOpenAccess W2480340708 @default.
- W2480340708 hasPrimaryLocation W24803407081 @default.
- W2480340708 hasRelatedWork W1507486876 @default.
- W2480340708 hasRelatedWork W1966599431 @default.
- W2480340708 hasRelatedWork W1971885031 @default.
- W2480340708 hasRelatedWork W1989914560 @default.
- W2480340708 hasRelatedWork W2075051921 @default.
- W2480340708 hasRelatedWork W2075429854 @default.
- W2480340708 hasRelatedWork W2086406769 @default.
- W2480340708 hasRelatedWork W2133125506 @default.
- W2480340708 hasRelatedWork W2168811052 @default.
- W2480340708 hasRelatedWork W2486847109 @default.
- W2480340708 hasVolume "26" @default.
- W2480340708 isParatext "false" @default.