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• W2480351924 endingPage "53807" @default.
• W2480351924 startingPage "53797" @default.
• W2480351924 abstract "Memantine is approved for the treatment of advanced Alzheimer´s disease (AD) and reduces glutamate-mediated neuronal excitotoxicity by antagonism of N-methyl-D-aspartate receptors. In the pathophysiology of AD immune responses deviate and infectious side effects are observed during memantine therapy. However, the particular effects of memantine on human T lymphocytes are unresolved. Here, we provide evidence that memantine blocks Kv1.3 potassium channels, inhibits CD3-antibody- and alloantigen-induced proliferation and suppresses chemokine-induced migration of peripheral blood T cells of healthy donors. Concurrent with the in vitro data, CD4+ T cells from AD patients receiving therapeutic doses of memantine show a transient decline of Kv1.3 channel activity and a long-lasting reduced proliferative response to alloantigens in mixed lymphocyte reactions. Furthermore, memantine treatment provokes a profound depletion of peripheral blood memory CD45RO+ CD4+ T cells. Thus, standard doses of memantine profoundly reduce T cell responses in treated patients through blockade of Kv1.3 channels. This may normalize deviant immunopathology in AD and contribute to the beneficial effects of memantine, but may also account for the enhanced infection rate." @default.
• W2480351924 created "2016-08-23" @default.
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• W2480351924 date "2016-07-22" @default.
• W2480351924 modified "2023-10-05" @default.
• W2480351924 title "Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness" @default.
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• W2480351924 doi "https://doi.org/10.18632/oncotarget.10777" @default.
• W2480351924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5288222" @default.
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