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• W2480396822 abstract "Publisher Summary This chapter reviews technologies required to identify and separate tumor tissue from normal tissue and then extract genomic material (i.e., RNA or DNA) for analysis, which requires purification, amplification, and expression analysis of the gene or gene products. The common technology used to develop these genomic signatures involves tumor libraries using primary and metastatic cancers whose provenance is clear. These specimens may be frozen or more commonly are FFPE. Analysis requires extracting RNA from the tumor tissue, using it as a template for cDNA, and building a gene expression profile using a multigene microarray as commercially available. This approach requires a training set of samples used to develop the expression signature and a second set of samples used to validate the signature. Gene silencing through methylation has promulgated a new area of research known as epigenetics where post-translational changes are evaluated as they effect gene expression. It summarizes the important observations on tumor profiling in the context of clinical care. Most neoplastic disease can be traced to its site of origin by clinical or pathological features, thereby allowing the treating physician to choose appropriate therapy. Tumor genotypes and the resulting RNA or protein phenotypes are becoming increasingly important in our understanding of malignancy." @default.
• W2480396822 created "2016-08-23" @default.
• W2480396822 creator A5045169979 @default.
• W2480396822 creator A5075755065 @default.
• W2480396822 creator A5088310160 @default.
• W2480396822 date "2010-01-01" @default.
• W2480396822 modified "2023-10-16" @default.
• W2480396822 title "Gene Expression Analysis for Tumor Profiling" @default.
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