Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480452012> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2480452012 endingPage "174" @default.
- W2480452012 startingPage "164" @default.
- W2480452012 abstract "Citrus limonoids are a class of chemically related compounds present in lemon, lime, orange and grapefruit. We have shown that nomilin and a limonoid glucoside mixture are potent inhibitors of prolifertation of estrogen receptor-negative (ER-) and -positive (ER+) human breast cancer cells in culture. In the present experiments, we tested deacetylnomilin, deoxylimonin, ichangin, isoobacunoic acid, limonol, limonin carboxymethoxime, methyl deoxylimonate, methylnomilinate methyl deacetylnomilinate, methyl isolimonate, nomilin glucoside, nomilinic acid glucoside, 7a-obacunol, obacunone and obacunone glucoside for their ability to inhibit the proliferation of MDA-MB-435 ER- and MCF-7 ER+ human breast cancer cells. In ER- cells, limonin methoxime and deacetylnomilin were the most effective inhibitors having IC50s of 0.02 and 0.07 ug/mL respectively. In ER+ cells, deacetylnomilin, obacunone and methyl nomilinate were the most effective inhibitors of proliferation having IC50s of 0.005, 0.009 and 0.01 ug/mL respectively. Maximum tolerated dose studies were conducted in nude mice for limonin and the glucoside" @default.
- W2480452012 created "2016-08-23" @default.
- W2480452012 creator A5001342084 @default.
- W2480452012 creator A5044367380 @default.
- W2480452012 creator A5057541874 @default.
- W2480452012 creator A5077977986 @default.
- W2480452012 creator A5090206101 @default.
- W2480452012 date "2000-07-30" @default.
- W2480452012 modified "2023-10-15" @default.
- W2480452012 title "Inhibition of Human Breast Cancer Cells by Citrus Limonoids" @default.
- W2480452012 doi "https://doi.org/10.1021/bk-2000-0758.ch012" @default.
- W2480452012 hasPublicationYear "2000" @default.
- W2480452012 type Work @default.
- W2480452012 sameAs 2480452012 @default.
- W2480452012 citedByCount "41" @default.
- W2480452012 countsByYear W24804520122012 @default.
- W2480452012 countsByYear W24804520122013 @default.
- W2480452012 countsByYear W24804520122016 @default.
- W2480452012 countsByYear W24804520122017 @default.
- W2480452012 countsByYear W24804520122019 @default.
- W2480452012 countsByYear W24804520122020 @default.
- W2480452012 countsByYear W24804520122021 @default.
- W2480452012 countsByYear W24804520122022 @default.
- W2480452012 crossrefType "book-chapter" @default.
- W2480452012 hasAuthorship W2480452012A5001342084 @default.
- W2480452012 hasAuthorship W2480452012A5044367380 @default.
- W2480452012 hasAuthorship W2480452012A5057541874 @default.
- W2480452012 hasAuthorship W2480452012A5077977986 @default.
- W2480452012 hasAuthorship W2480452012A5090206101 @default.
- W2480452012 hasConcept C121608353 @default.
- W2480452012 hasConcept C126322002 @default.
- W2480452012 hasConcept C142724271 @default.
- W2480452012 hasConcept C185592680 @default.
- W2480452012 hasConcept C204787440 @default.
- W2480452012 hasConcept C2776137196 @default.
- W2480452012 hasConcept C2779645884 @default.
- W2480452012 hasConcept C2781347565 @default.
- W2480452012 hasConcept C2994423619 @default.
- W2480452012 hasConcept C55493867 @default.
- W2480452012 hasConcept C71240020 @default.
- W2480452012 hasConcept C71924100 @default.
- W2480452012 hasConcept C86803240 @default.
- W2480452012 hasConcept C96232424 @default.
- W2480452012 hasConcept C98274493 @default.
- W2480452012 hasConceptScore W2480452012C121608353 @default.
- W2480452012 hasConceptScore W2480452012C126322002 @default.
- W2480452012 hasConceptScore W2480452012C142724271 @default.
- W2480452012 hasConceptScore W2480452012C185592680 @default.
- W2480452012 hasConceptScore W2480452012C204787440 @default.
- W2480452012 hasConceptScore W2480452012C2776137196 @default.
- W2480452012 hasConceptScore W2480452012C2779645884 @default.
- W2480452012 hasConceptScore W2480452012C2781347565 @default.
- W2480452012 hasConceptScore W2480452012C2994423619 @default.
- W2480452012 hasConceptScore W2480452012C55493867 @default.
- W2480452012 hasConceptScore W2480452012C71240020 @default.
- W2480452012 hasConceptScore W2480452012C71924100 @default.
- W2480452012 hasConceptScore W2480452012C86803240 @default.
- W2480452012 hasConceptScore W2480452012C96232424 @default.
- W2480452012 hasConceptScore W2480452012C98274493 @default.
- W2480452012 hasLocation W24804520121 @default.
- W2480452012 hasOpenAccess W2480452012 @default.
- W2480452012 hasPrimaryLocation W24804520121 @default.
- W2480452012 hasRelatedWork W1530903144 @default.
- W2480452012 hasRelatedWork W1963781683 @default.
- W2480452012 hasRelatedWork W1979986761 @default.
- W2480452012 hasRelatedWork W1996635313 @default.
- W2480452012 hasRelatedWork W2035013389 @default.
- W2480452012 hasRelatedWork W2038621814 @default.
- W2480452012 hasRelatedWork W2046522090 @default.
- W2480452012 hasRelatedWork W2067081871 @default.
- W2480452012 hasRelatedWork W2336891512 @default.
- W2480452012 hasRelatedWork W2480452012 @default.
- W2480452012 isParatext "false" @default.
- W2480452012 isRetracted "false" @default.
- W2480452012 magId "2480452012" @default.
- W2480452012 workType "book-chapter" @default.