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- W2480456513 endingPage "8063" @default.
- W2480456513 startingPage "8050" @default.
- W2480456513 abstract "It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Research Research Domain Criteria framework. However, new observations encourage a different perspective. Anatomical studies show that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated and used to assemble states of fear and anxiety. Imaging studies in humans and monkeys show that the Ce and BST exhibit similar functional profiles. Both regions are sensitive to a range of aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs and symptoms of fear and anxiety; both show phasic responses to short-lived threat; and both show heightened activity during sustained exposure to diffusely threatening contexts. Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat. These observations compel a reconsideration of the central extended amygdala9s contributions to fear and anxiety and its role in neuropsychiatric disease." @default.
- W2480456513 created "2016-08-23" @default.
- W2480456513 creator A5026773840 @default.
- W2480456513 creator A5049400083 @default.
- W2480456513 date "2016-08-03" @default.
- W2480456513 modified "2023-10-18" @default.
- W2480456513 title "Contributions of the Central Extended Amygdala to Fear and Anxiety" @default.
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