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- W2480456976 abstract "Metformin is a widely used medicine to treat type 2 diabetes. Clinical studies have shown that metformin can reduce cancer incidence, yet the molecular mechanism of which is not totally understood. The p53-related p63 plays a critical role in regulation of cell proliferation, apoptosis, differentiation and development. We and others have shown that the major isform of p63 proteins, ΔNp63α, is important in regulation of squamous carcinoma cell proliferation, survival and cancer metastasis (Bergholz et al.,Oncogene 33:212-224, 2014;Li et al.,CDDis,2013, e943; doi:10.10384). In this study, we show that metformin can induce instability of ΔNp63α protein, leading to subsequent anoikis. In addition, glucose restriction or inhibition of glycolysis significantly sensitizes cells to metformin. Furthermore, we show that integrin β1 is involved in this process. Taken together, this study reveals a novel molecular mechanism by which metformin inhibits squamous carcinoma formation in vitro and in vivo. Citation Format: Yong Yi, Zhi-Xiong Jim Xiao. Inhibition of glycolysis sensitizes cancer cells to metformin-induced anoikis. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2856." @default.
- W2480456976 created "2016-08-23" @default.
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- W2480456976 date "2016-07-15" @default.
- W2480456976 modified "2023-09-26" @default.
- W2480456976 title "Abstract 2856: Inhibition of glycolysis sensitizes cancer cells to metformin-induced anoikis" @default.
- W2480456976 doi "https://doi.org/10.1158/1538-7445.am2016-2856" @default.
- W2480456976 hasPublicationYear "2016" @default.
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