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- W2480492848 abstract "The safety assessment of a food or food additive is a risk assessment of a cumulative food or additive use. It is limited by current scientific knowledge and often involves considerable judgment about science. The safety standard which is used to support regulatory actions varies according to product type, history of use, and regulatory category. Traditionally, food additives are considered safe for food use when a large safety factor or margin of safety exists between the amount the consumer ingests and the amount that causes no adverse effects in the animal used to test for food additive safety. This approach may not be sufficient for estimating safety when there are high intended use levels, significant inter- and intra-species variation in physiological effects or metabolism of an additive, or when adverse health effects are different in animals and humans. Also, foods are increasingly being tested for their role in disease prevention or" @default.
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- W2480492848 date "1992-02-14" @default.
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- W2480492848 title "Usefulness of Clinical Studies in Establishing Safety of Food Products" @default.
- W2480492848 doi "https://doi.org/10.1021/bk-1992-0484.ch011" @default.
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