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• W2480521660 abstract "Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes, IN [1] and RT [2]. Herein, we present chemical synthesis of eleven methylenebisphosphonates (BPs) with their NMR and HRMS analysis synthesized via five different ways. Also, we present data on inhibition of HIV RT catalyzed phosphorolysis and polymerization by synthesized BPs using two methods based on denaturing urea PAGE. Tests were also performed for thymidine analogue mutations reverse transcriptase (TAM RT), which was expressed and purified for that. Structure-activity relationships and inhibitory activity data of synthesized BPs are presented in Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity [2]." @default.
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• W2480521660 date "2016-09-01" @default.
• W2480521660 modified "2023-10-04" @default.
• W2480521660 title "Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase" @default.
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• W2480521660 doi "https://doi.org/10.1016/j.dib.2016.07.039" @default.
• W2480521660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4978200" @default.
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