FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480572321> ?p ?o ?g. }

• W2480572321 abstract "The highly regulated processes of mitochondrial fusion, fission (division), and trafficking, collectively called mitochondrial dynamics, determine the cell-type specific morphology, intracellular distribution, and activity of these critical organelles. These processes modulate a variety of mitochondrial functions, allowing living cells to respond properly to frequently changing environmental conditions. The tightly controlled balance between fusion and fission is of utmost importance in the highly energy demanding cells, such as cardiac and skeletal muscles and neuronal cells. A shift towards fission leads to mitochondrial fragmentation, whereas a shift towards fusion results in the formation of the large mitochondrial networks. Large dynamin-related Mfn1, Mfn2, and OPA1 constitute the core machinery promoting mitochondrial fusion. Mfn1 and Mfn2, localized on the mitochondrial outer membrane (MOM), mediate MOM fusion, whereas OPA1, located in the mitochondrial inner membrane (MIM), promotes fusion of the MIM as well as cristae remodeling. A dynamin-related Drp1 along with Fis1 and Mff are the core components of mitochondrial fission machinery in mammalian cells. All known core mammalian fission proteins are localized in the MOM, but it is very little known about MIM fission. Currently, the most characterized defects in components involved in mitochondrial dynamics have been found in inherited neurological and neurodegenerative disorders. Although intracellular architecture of mature cardiomyocytes greatly restricts mitochondrial dynamics, this process occurs in the heart, albeit much slower than in other cell types. Emerging evidence strongly suggests that impairment of mitochondrial dynamics causes mitochondrial dysfunction and can contribute to the pathogenesis of various cardiovascular diseases (CVDs), including ischemia-reperfusion injury (IRI), various cariomyopathies, and heart failure (HF). Pharmacological targeting components of the mitochondrial fusion and fission machineries to normalize normal mitochondrial numbers, morphology, and function may be a novel therapeutic modality for CVD treatment. Despite significant progress in our understanding of the molecular mechanisms of mitochondrial dynamics in the heart, further extensive research is needed to translate this knowledge into the development of efficient therapies for CVD." @default.
• W2480572321 created "2016-08-23" @default.
• W2480572321 creator A5022739391 @default.
• W2480572321 date "2014-01-01" @default.
• W2480572321 modified "2023-09-24" @default.
• W2480572321 title "The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease" @default.
• W2480572321 cites W1030859426 @default.
• W2480572321 cites W132197661 @default.
• W2480572321 cites W1493752155 @default.
• W2480572321 cites W1508962729 @default.
• W2480572321 cites W1522450427 @default.
• W2480572321 cites W1529592271 @default.
• W2480572321 cites W174969222 @default.
• W2480572321 cites W1826569511 @default.
• W2480572321 cites W1877873625 @default.
• W2480572321 cites W1960363048 @default.
• W2480572321 cites W1963577160 @default.
• W2480572321 cites W1963940229 @default.
• W2480572321 cites W1965513315 @default.
• W2480572321 cites W1966201817 @default.
• W2480572321 cites W1966241472 @default.
• W2480572321 cites W1967445833 @default.
• W2480572321 cites W1969373094 @default.
• W2480572321 cites W1969769741 @default.
• W2480572321 cites W1970248089 @default.
• W2480572321 cites W1970302092 @default.
• W2480572321 cites W1970308606 @default.
• W2480572321 cites W1970979133 @default.
• W2480572321 cites W1971805318 @default.
• W2480572321 cites W1972044649 @default.
• W2480572321 cites W1972070850 @default.
• W2480572321 cites W1972398314 @default.
• W2480572321 cites W1972476228 @default.
• W2480572321 cites W1973281235 @default.
• W2480572321 cites W1973821281 @default.
• W2480572321 cites W1973926398 @default.
• W2480572321 cites W1974958475 @default.
• W2480572321 cites W1976779549 @default.
• W2480572321 cites W1978268445 @default.
• W2480572321 cites W1979489548 @default.
• W2480572321 cites W1979645469 @default.
• W2480572321 cites W1980100638 @default.
• W2480572321 cites W1980103053 @default.
• W2480572321 cites W1980232211 @default.
• W2480572321 cites W1980617309 @default.
• W2480572321 cites W1980955874 @default.
• W2480572321 cites W1985119207 @default.
• W2480572321 cites W1986996580 @default.
• W2480572321 cites W1987097693 @default.
• W2480572321 cites W1987232285 @default.
• W2480572321 cites W1987459699 @default.
• W2480572321 cites W1987698712 @default.
• W2480572321 cites W1987845572 @default.
• W2480572321 cites W1989540421 @default.
• W2480572321 cites W1989554731 @default.
• W2480572321 cites W1989560849 @default.
• W2480572321 cites W1990069067 @default.
• W2480572321 cites W1991189623 @default.
• W2480572321 cites W1991744562 @default.
• W2480572321 cites W1992080421 @default.
• W2480572321 cites W1993398538 @default.
• W2480572321 cites W1993490757 @default.
• W2480572321 cites W1993696187 @default.
• W2480572321 cites W1996764498 @default.
• W2480572321 cites W1998076098 @default.
• W2480572321 cites W1998332234 @default.
• W2480572321 cites W1999053124 @default.
• W2480572321 cites W1999095464 @default.
• W2480572321 cites W1999512927 @default.
• W2480572321 cites W1999566059 @default.
• W2480572321 cites W1999793372 @default.
• W2480572321 cites W2000719268 @default.
• W2480572321 cites W2001806301 @default.
• W2480572321 cites W2002321863 @default.
• W2480572321 cites W2003301062 @default.
• W2480572321 cites W2003705213 @default.
• W2480572321 cites W2004284307 @default.
• W2480572321 cites W2005038133 @default.
• W2480572321 cites W2005607645 @default.
• W2480572321 cites W2005673220 @default.
• W2480572321 cites W2005942480 @default.
• W2480572321 cites W2006787533 @default.
• W2480572321 cites W2006851801 @default.
• W2480572321 cites W2007289467 @default.
• W2480572321 cites W2007407888 @default.
• W2480572321 cites W2007552109 @default.
• W2480572321 cites W2007891746 @default.
• W2480572321 cites W2008362068 @default.
• W2480572321 cites W2009278410 @default.
• W2480572321 cites W2009547397 @default.
• W2480572321 cites W2009909952 @default.
• W2480572321 cites W2012014117 @default.
• W2480572321 cites W2014115155 @default.
• W2480572321 cites W2014229034 @default.
• W2480572321 cites W2015133213 @default.
• W2480572321 cites W2015594876 @default.
• W2480572321 cites W2016581978 @default.
• W2480572321 cites W2016936426 @default.
• W2480572321 cites W2018019380 @default.
• W2480572321 cites W2018801689 @default.

• next