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- W2480653996 endingPage "636" @default.
- W2480653996 startingPage "619" @default.
- W2480653996 abstract "This chapter reviews the pathophysiology, clinical characteristics, diagnosis, and therapeutic approach to TSH-secreting adenomas. The coexistence of hyperthyroidism, a pituitary mass and excessive thyrotropin production demonstrated using a thyroid-stimulating hormone (TSH) bioassay, was first described in 1960. The diagnosis of thyrotropin- secreting adenomas (TSPA) is based on the demonstration of elevated serum thyroid hormones in the presence of elevated or normal TSH levels. The possibility of making this diagnosis was compromised at first by the inability of early radioimmunoassays to distinguish between normal and suppressed TSH levels. In patients with primary thyroid disease, which is by far the most common cause of hyperthyroidism, TSH levels are suppressed by the elevated peripheral thyroid hormones, and are thus undetectable in serum. When TSH itself is responsible for thyroid hyperstimulation, it is readily detected, being either inappropriately in the normal range or actually elevated. Because of the past laboratory limitations, patients were often misdiagnosed as having primary hyperthyroidism, leading to erroneous therapeutic decisions. The introduction of sensitive TSH immunoassays led to an improvement in the detection rate of these pituitary tumors. Nevertheless, they remain a rare disorder, being the least prevalent among all pituitary adenomas." @default.
- W2480653996 created "2016-08-23" @default.
- W2480653996 creator A5015814834 @default.
- W2480653996 creator A5027092637 @default.
- W2480653996 date "2011-01-01" @default.
- W2480653996 modified "2023-10-05" @default.
- W2480653996 title "Thyrotropin-Secreting Pituitary Tumors" @default.
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