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- W2480664037 endingPage "89" @default.
- W2480664037 startingPage "65" @default.
- W2480664037 abstract "Birds have a unique organ for primary B lymphopoiesis, the bursa of Fabricius. Thus, avian B cell development can be classified into pre-bursal, bursal and post-bursal stages. During embryonic development, pre-bursal B cell precursors migrate in a single wave into the bursal mesenchyme; cells which express cell surface immunoglobulin as a consequence of productive gene rearrangement subsequently colonize the follicle anlagen. B cells then proliferate rapidly in bursal follicles and diversify their receptor repertoire by means of gene conversion. After hatch, the formerly homogenous follicles separate into two compartments: an outer cortex and a central medulla. Starting around the time of hatch, B cells emigrate from the bursa, predominantly from the follicle cortex, to colonize peripheral lymphoid tissues. In the periphery, naïve B cells encounter antigen, undergo a germinal center reaction and differentiate into antibody-secreting plasma cells. Many aspects of these processes are regulated by cytokines. While the function of BAFF and CD40L on peripheral B cells is largely conserved between birds and mammals, both of these TNF family members play unique roles in the bursa of Fabricius." @default.
- W2480664037 created "2016-08-23" @default.
- W2480664037 creator A5044175561 @default.
- W2480664037 creator A5074551684 @default.
- W2480664037 date "2014-01-01" @default.
- W2480664037 modified "2023-10-15" @default.
- W2480664037 title "B Cells, the Bursa of Fabricius and the Generation of Antibody Repertoires" @default.
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