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- W2480854277 abstract "This chapter discusses drugs affecting the parasympathetic system. Acetylcholine is the transmitter released by all postganglionic parasympathetic nerves. It is also the transmitter released by a few postganglionic sympathetic nerves. The actions of acetylcholine released from postganglionic nerve endings are mimicked by the alkaloid muscarine and are antagonized by atropine, a competitive antagonist of acetylcholine at muscarinic junctions. The reason why acetylcholine can act at both nicotinic and muscarinic receptors is probably the fact that the acetylcholine molecule is relatively flexible and can assume different conformations. Moreover, an alkaloid, muscarine is present in the poisonous fungus Amanita muscaria. It is the prototype parasympathomimetic drug and has no nicotinic activity. Apart from peripheral effects because of the stimulation of muscarinic receptors, it also has stimulant effects on the central nervous system. In general, the actions of muscarinic agonist drugs mimic the effects of stimulation of parasympathetic postganglionic nerves although there are some minor differences between the actions of the different drugs. The effects are widespread throughout the body because of the large number of organs that receive an innervation through postganglionic parasympathetic nerves." @default.
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- W2480854277 date "1989-01-01" @default.
- W2480854277 modified "2023-10-17" @default.
- W2480854277 title "Drugs affecting the parasympathetic system" @default.
- W2480854277 doi "https://doi.org/10.1016/b978-0-7236-1271-1.50012-2" @default.
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