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- W2480894805 endingPage "286" @default.
- W2480894805 startingPage "267" @default.
- W2480894805 abstract "Circulating tumor cells (CTCs) have provided researchers with ample information about metastatic cancer. This chapter discusses how adhesion molecules, namely E-selectin, can be used to recapitulate the early steps of CTC adhesion in vitro to achieve capture and characterization of CTCs from patients' blood samples. It also discusses how this interaction may be exploited to target and kill CTCs in vivo. Most work has centered around the detection and isolation of CTCs from blood samples of cancer patients, although in recent years, research has expanded to the identification of important mutations present in CTCs, epithelial-mesenchymal transition (EMT) status of CTCs, and the correlation of CTC count with drug efficacy. Many studies have shown in both animal models and human studies that CTC count correlates with prognosis, suggesting that a higher CTC count is generally indicative of a worse survival rate and greater disease progression." @default.
- W2480894805 created "2016-08-23" @default.
- W2480894805 creator A5010317825 @default.
- W2480894805 creator A5081005464 @default.
- W2480894805 date "2016-04-04" @default.
- W2480894805 modified "2023-09-23" @default.
- W2480894805 title "Selectin-Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment" @default.
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