Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480902016> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2480902016 abstract "Background: This study evaluated the therapeutic efficacy of combining vascular disrupting agents with antiangiogenic agents. Materials and Methods: Human clear cell renal carcinoma (Caki-1) tumors were established in nude mice. Treatments consisted of Avastin (2 mg/kg) administered twice a week; CA4P (100 mg/kg) or OXi4503 (25 mg/kg) administered 3 times a week for a period of 2 weeks; or a combination of Avastin and CA4P or OXi4503. Tumor response was assessed by growth delay. Results: The tumor growth delays were 8, 6, and 18 days for Avastin, CA4P, and OXi4503, respectively.When the two therapies were combined, there was a significantly greater tumor response than what was achieved with single-agent treatments. For example, Avastin plus CA4P led to a growth delay of 13 days, and 27 days for Avastin plus OXi4503. Conclusion: Vascular-directed therapies that include both antiangiogenic and vascular disrupting therapeutics can result in significantly enhanced antitumor effects. Blood vessels in tumors have long been recognized to differ greatly in structure and function from those found in normal tissues (1). Tumor vasculature is highly irregular, heterogenic and tortuous, and typically lacks smooth muscle and pericyte support. Functionally, these tumor vessels are highly permeable and angiogenic. Despite these abnormalities, a tumor's growth, spread, and survival are utterly dependent on its ability to maintain a functional blood vessel network (2). Consequently, intense research has pursued and successfully established a variety of new therapeutic approaches and agents directed specifically against this component of solid tumors." @default.
- W2480902016 created "2016-08-23" @default.
- W2480902016 creator A5059909608 @default.
- W2480902016 creator A5083947131 @default.
- W2480902016 date "2008-01-01" @default.
- W2480902016 modified "2023-09-24" @default.
- W2480902016 title "DualTargetingofTumorVasculature:CombiningAvastinand VascularDisruptingAgents(CA4PorOXi4503)" @default.
- W2480902016 cites W1593154204 @default.
- W2480902016 cites W1763129547 @default.
- W2480902016 cites W190481955 @default.
- W2480902016 cites W1966726954 @default.
- W2480902016 cites W1968515430 @default.
- W2480902016 cites W1974448776 @default.
- W2480902016 cites W1992375630 @default.
- W2480902016 cites W1993992036 @default.
- W2480902016 cites W1994297035 @default.
- W2480902016 cites W2024304301 @default.
- W2480902016 cites W2046507292 @default.
- W2480902016 cites W2046714964 @default.
- W2480902016 cites W2051628747 @default.
- W2480902016 cites W2096001845 @default.
- W2480902016 cites W2098114704 @default.
- W2480902016 cites W2100785570 @default.
- W2480902016 cites W2114159573 @default.
- W2480902016 cites W2121491089 @default.
- W2480902016 cites W2124863710 @default.
- W2480902016 cites W2129331774 @default.
- W2480902016 cites W2135691661 @default.
- W2480902016 cites W2135706817 @default.
- W2480902016 cites W2148066280 @default.
- W2480902016 cites W2156071539 @default.
- W2480902016 cites W2157769714 @default.
- W2480902016 cites W2162704033 @default.
- W2480902016 cites W2338347846 @default.
- W2480902016 cites W2587982299 @default.
- W2480902016 hasPublicationYear "2008" @default.
- W2480902016 type Work @default.
- W2480902016 sameAs 2480902016 @default.
- W2480902016 citedByCount "0" @default.
- W2480902016 crossrefType "journal-article" @default.
- W2480902016 hasAuthorship W2480902016A5059909608 @default.
- W2480902016 hasAuthorship W2480902016A5083947131 @default.
- W2480902016 hasConcept C121608353 @default.
- W2480902016 hasConcept C123012128 @default.
- W2480902016 hasConcept C126322002 @default.
- W2480902016 hasConcept C185592680 @default.
- W2480902016 hasConcept C202751555 @default.
- W2480902016 hasConcept C2777472916 @default.
- W2480902016 hasConcept C2777663904 @default.
- W2480902016 hasConcept C2780427682 @default.
- W2480902016 hasConcept C502942594 @default.
- W2480902016 hasConcept C55493867 @default.
- W2480902016 hasConcept C71924100 @default.
- W2480902016 hasConcept C98274493 @default.
- W2480902016 hasConceptScore W2480902016C121608353 @default.
- W2480902016 hasConceptScore W2480902016C123012128 @default.
- W2480902016 hasConceptScore W2480902016C126322002 @default.
- W2480902016 hasConceptScore W2480902016C185592680 @default.
- W2480902016 hasConceptScore W2480902016C202751555 @default.
- W2480902016 hasConceptScore W2480902016C2777472916 @default.
- W2480902016 hasConceptScore W2480902016C2777663904 @default.
- W2480902016 hasConceptScore W2480902016C2780427682 @default.
- W2480902016 hasConceptScore W2480902016C502942594 @default.
- W2480902016 hasConceptScore W2480902016C55493867 @default.
- W2480902016 hasConceptScore W2480902016C71924100 @default.
- W2480902016 hasConceptScore W2480902016C98274493 @default.
- W2480902016 hasLocation W24809020161 @default.
- W2480902016 hasOpenAccess W2480902016 @default.
- W2480902016 hasPrimaryLocation W24809020161 @default.
- W2480902016 hasRelatedWork W1538636606 @default.
- W2480902016 hasRelatedWork W1970395106 @default.
- W2480902016 hasRelatedWork W1975407113 @default.
- W2480902016 hasRelatedWork W1988012391 @default.
- W2480902016 hasRelatedWork W1993415191 @default.
- W2480902016 hasRelatedWork W1996110214 @default.
- W2480902016 hasRelatedWork W1998684576 @default.
- W2480902016 hasRelatedWork W2017749218 @default.
- W2480902016 hasRelatedWork W2029852728 @default.
- W2480902016 hasRelatedWork W2039347896 @default.
- W2480902016 hasRelatedWork W2046714964 @default.
- W2480902016 hasRelatedWork W2058190266 @default.
- W2480902016 hasRelatedWork W2072226806 @default.
- W2480902016 hasRelatedWork W2073460574 @default.
- W2480902016 hasRelatedWork W2096001845 @default.
- W2480902016 hasRelatedWork W2206792244 @default.
- W2480902016 hasRelatedWork W2336926456 @default.
- W2480902016 hasRelatedWork W2365446422 @default.
- W2480902016 hasRelatedWork W2755513116 @default.
- W2480902016 hasRelatedWork W2183953400 @default.
- W2480902016 isParatext "false" @default.
- W2480902016 isRetracted "false" @default.
- W2480902016 magId "2480902016" @default.
- W2480902016 workType "article" @default.