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- W2481014256 abstract "Abstract We have observed that various types of rat tumor cells express glycoconjugates on their cell surfaces which allow binding of the hepatic asialoglycoprotein receptor, a lectin with specificity for D-galactose and N-acetyl-D-galactosamine. The tumor types tested were L 5222 leukemia, Walker 256 carcinosarcoma, lymphoma and Yoshida hepatoma. All of them bound the asialoglycoprotein receptor whereas normal cells in general did not. Tryptic digestion of L 5222 leukemia cell membranes released glycopeptides which strongly inhibited the binding of the asialoglycoprotein receptor. Reactive membrane glycoproteins could be solubilized by 2 M urea or β-octylglucose extraction and could be enriched by chromatography on PNA beads. We conclude that the hepatic asialoglycoprotein receptor recognizes tumor specific glycoproteins on a number of different rat tumor cell types." @default.
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- W2481014256 date "1984-01-01" @default.
- W2481014256 modified "2023-09-26" @default.
- W2481014256 title "A General Tumor Marker in Rats which is Recognized by the Hepatic Asialoglycoprotein Receptor" @default.
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- W2481014256 doi "https://doi.org/10.1016/b978-0-08-030764-0.50136-1" @default.
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