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• W2481064327 abstract "Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) is a technique well suited for analysis of biological specimens. This tutorial review focuses on recent advancements and applications of IR-MALDESI MSI to better understand key biological questions. Through optimization of user-defined source parameters, comprehensive and quantitative MSI data can be obtained for a variety of analytes. The effect of an ice matrix layer is well defined in the context of desorption dynamics and resulting ion abundance. Optimized parameters and careful control of conditions affords quantitative MSI data which provides valuable information for targeted, label-free drug distribution studies and untargeted metabolomic datasets. Challenges and limitations of MSI using IR-MALDESI are addressed in the context of the bioimaging field." @default.
• W2481064327 created "2016-08-23" @default.
• W2481064327 creator A5011472766 @default.
• W2481064327 creator A5082323732 @default.
• W2481064327 date "2016-01-01" @default.
• W2481064327 modified "2023-10-18" @default.
• W2481064327 title "Infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging analysis of biospecimens" @default.
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• W2481064327 doi "https://doi.org/10.1039/c6an01189f" @default.
• W2481064327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5007172" @default.
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• W2481064327 hasPublicationYear "2016" @default.
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