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- W2481103992 abstract "Neuropsychiatric symptoms (NPS) increase the likelihood of progression from Mild Cognitive Impairment (MCI) to dementia. Some studies have shown higher levels of depression, anxiety, and delusions in female patients and higher levels of apathy and aggression in male patients. The objective of the present study is to establish classes of patients with incident MCI based on their neuropsychiatric symptoms. Further we sought to determine if the class structure is different between male and female patients and how class membership relates to risk of progression to dementia for male and female patients separately. Longitudinal data from 540 patients with MCI from 29 Alzheimer Disease Centers was utilized. Latent Class and Survival Analyses were used to predict hazard of progression to dementia based on neuropsychiatric symptoms measured using the Neuropsychiatric Inventory (NPI). Analyses were conducted separately by sex to determine if men and women had different class structures and hazard of progression. Class structure varied as a function of sex. An asymptomatic class (75%) and an affective class (25%) were found for men while an asymptomatic class (56%), an affective class (37%), and a severe class (7%) were found for women. For men, the affective class had a hazard ratio of 1.93 (CI: 0.91-4.14) of progression to dementia compared to the asymptomatic class. For women, the severe class was more than three times as likely to progress to dementia as the asymptomatic class (HR: 3.79, CI: 2.01-7.13) and the affective class was nearly twice as likely as the asymptomatic class to progress to dementia (HR: 1.82, CI: 1.11-2.98)." @default.
- W2481103992 created "2016-08-23" @default.
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- W2481103992 date "2015-07-01" @default.
- W2481103992 modified "2023-10-16" @default.
- W2481103992 title "P3-130: Sex differences in neuropsychiatric symptoms in MCI and risk of dementia" @default.
- W2481103992 doi "https://doi.org/10.1016/j.jalz.2015.06.998" @default.
- W2481103992 hasPublicationYear "2015" @default.
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